S5VN62 · S5VN62_9PLEU
- ProteinRhodopsin
- GeneRH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids265 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling.
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 80 | Plays an important role in the conformation switch to the active conformation | |||
Binding site | 168 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 246 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | photoreceptor outer segment | |
Molecular Function | G protein-coupled photoreceptor activity | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to light stimulus | |
Biological Process | phototransduction | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRhodopsin
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Carangaria > Pleuronectiformes > Pleuronectoidei > Paralichthyidae > Xystreurys
Accessions
- Primary accessionS5VN62
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-30 | Helical | |||
Transmembrane | 42-62 | Helical | |||
Transmembrane | 82-100 | Helical | |||
Transmembrane | 121-140 | Helical | |||
Transmembrane | 170-190 | Helical | |||
Transmembrane | 221-243 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 77↔154 | ||||
Modified residue | 263 | N6-(retinylidene)lysine | |||
Post-translational modification
Contains one covalently linked retinal chromophore.
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 21-235 | G-protein coupled receptors family 1 profile | |||
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Keywords
- Domain
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusFragment
- Length265
- Mass (Da)29,556
- Last updated2013-10-16 v1
- ChecksumB2DF824A1C14968C
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 265 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF312139 EMBL· GenBank· DDBJ | AGS78650.1 EMBL· GenBank· DDBJ | Genomic DNA |