S5VN62 · S5VN62_9PLEU

Function

function

Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site, binding site.

126520406080100120140160180200220240260
Type
IDPosition(s)Description
Site80Plays an important role in the conformation switch to the active conformation
Binding site168Zn2+ (UniProtKB | ChEBI)
Binding site246Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentphotoreceptor outer segment
Molecular FunctionG protein-coupled photoreceptor activity
Molecular Functionmetal ion binding
Biological Processcellular response to light stimulus
Biological Processphototransduction
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Rhodopsin

Gene names

    • Name
      RH1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AL2008-506
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Carangaria > Pleuronectiformes > Pleuronectoidei > Paralichthyidae > Xystreurys

Accessions

  • Primary accession
    S5VN62

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-30Helical
Transmembrane42-62Helical
Transmembrane82-100Helical
Transmembrane121-140Helical
Transmembrane170-190Helical
Transmembrane221-243Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond, modified residue.

Type
IDPosition(s)Description
Disulfide bond77↔154
Modified residue263N6-(retinylidene)lysine

Post-translational modification

Contains one covalently linked retinal chromophore.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-235G-protein coupled receptors family 1 profile

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Fragment
  • Length
    265
  • Mass (Da)
    29,556
  • Last updated
    2013-10-16 v1
  • Checksum
    B2DF824A1C14968C
PAAYAVLGAYMFLLILLGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAVERWMVVCKPISNFRFGENHAIMGLACTWLGAAACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFVCHFCIPLTIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLVCWCPYAGVAWYIFSNQGSEFGPLFMTIPAFFAKSS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue265

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF312139
EMBL· GenBank· DDBJ
AGS78650.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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