S5U054 · S5U054_ALTSO

  • Protein
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • Gene
    SdhB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster.
[3Fe-4S] cluster (UniProtKB | Rhea| CHEBI:21137 )

Note: Binds 1 [3Fe-4S] cluster.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Function3 iron, 4 sulfur cluster binding
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionelectron transfer activity
Molecular Functionmetal ion binding
Molecular Functionsuccinate dehydrogenase (quinone) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • EC number

Gene names

    • Name
      SdhB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 1180-2
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Alternaria > Alternaria sect. Porri

Accessions

  • Primary accession
    S5U054

Subcellular Location

Mitochondrion inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region45-73Disordered
Domain89-1682Fe-2S ferredoxin-type
Domain210-2404Fe-4S ferredoxin-type

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    34,764
  • Last updated
    2013-10-16 v1
  • Checksum
    D09AD2EF7D2E158D
MASIRAFTRLATSDLVPVRPAVFSRGFASVNDVHAREPISKIAEKIAPDASRSPVPESKTSTVPEPEPSKDAKTKTFHIYRWNPDEPTSKPKMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIPTDTTKESRIYPLPHMYVVKDLVPDMTLFYKQYRSVKPYLQRSTAAPDGREFRQSKEDRKKLDGLYECILCACCSTSCPSYWWNQEEYLGPAVLLQSYRWIADSRDEKKAERQDALNNSMSLYRCYTILNCSRTCPKGLNPALAIAEIKKSMAFT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC517312
EMBL· GenBank· DDBJ
AGS56261.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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