S5TUE5 · S5TUE5_ENTCL

  • Protein
    Chaperonin GroEL
  • Gene
    groEL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

Catalytic activity

  • ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.
    EC:5.6.1.7 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

154650100150200250300350400450500
TypeIDPosition(s)Description
Binding site30-33ATP (UniProtKB | ChEBI)
Binding site51ATP (UniProtKB | ChEBI)
Binding site87-91ATP (UniProtKB | ChEBI)
Binding site415ATP (UniProtKB | ChEBI)
Binding site479-481ATP (UniProtKB | ChEBI)
Binding site495ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGroEL-GroES complex
Molecular FunctionATP binding
Molecular FunctionATP-dependent protein folding chaperone
Molecular Functionisomerase activity
Molecular Functionunfolded protein binding
Biological Processchaperone cofactor-dependent protein refolding
Biological Processprotein refolding
Biological Processresponse to heat

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chaperonin GroEL
  • EC number
  • Alternative names
    • 60 kDa chaperonin
    • Chaperonin-60
      (Cpn60
      )

Gene names

    • Name
      groEL
    • Synonyms
      groL
    • ORF names
      P3S46_08675
      , pCRE727_16
      , pNDM1_EC14653_00120
      , pYQ13500_017

Encoded on

  • Plasmid pCR16-ECL-NDM-1
  • Plasmid pECL3-NDM-1
  • Plasmid pNDM-ECN49
  • Plasmid pNDM-Ec1GN574
  • Plasmid pNDM-HF727
  • Plasmid pNDM1_EC14653
  • Plasmid pPN2-ECL-NDM-1
  • Plasmid pYQ13500-NDM

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • CRE727
    • GN574
    • WCHECl-14653
    • EC-YQ13500
    • CR16
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex

Accessions

  • Primary accession
    S5TUE5
  • Secondary accessions
    • A0A0P8I575

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region527-546Disordered

Sequence similarities

Belongs to the chaperonin (HSP60) family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    546
  • Mass (Da)
    57,062
  • Last updated
    2013-10-16 v1
  • Checksum
    4E48091CE2FC367A
MAAKDIRFGEDARSKMVRGVNVLANAVKATLGPKGRNVVLQKSYGAPTITKDGVSVAKEIELADAFENMGAQMVKEVASKTSDNAGDGTTTATVLAQAFIREGMKAVAAGMNPMDLKRGIDQAVKAAVGELKSLSKPSSTSKEIAQVGAISANSDANIGDLIAQAMDKVGKEGVITVEEGSGLDNELDVVEGMQFDRGYLSPYFVNNQQSMSADLDDPFILLYDKKISNVRDLLPVLEGVAKAGKPLLIVAEEVEGEALATLVVNTIRGIVKVCAVKAPGFGDRRKAMLEDMAILTGGVVISEEVGLSLEKATIKDLGRAKKIQVSKENTTIIDGAGEGAGIEARIKQIKAQIEETSSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALIRAKAAIAGIKGVNEDQNHGIQIALRAMEAPLREIVTNAGDEPSVILNRVVEGSGAFGYNAANGEFGDMIEFGILDPTKVTRTALQNAASIAGLMITTEAMVAEAPKKDEPAMPAGGGMGGMGGMDF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC887917
EMBL· GenBank· DDBJ
AGS56781.1
EMBL· GenBank· DDBJ
Genomic DNA
KF976405
EMBL· GenBank· DDBJ
AHN60531.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ812998
EMBL· GenBank· DDBJ
AIM48565.1
EMBL· GenBank· DDBJ
Genomic DNA
KP765744
EMBL· GenBank· DDBJ
AKJ21421.1
EMBL· GenBank· DDBJ
Genomic DNA
KP868647
EMBL· GenBank· DDBJ
AKN19823.1
EMBL· GenBank· DDBJ
Genomic DNA
KP826704
EMBL· GenBank· DDBJ
AKN35257.1
EMBL· GenBank· DDBJ
Genomic DNA
KR059865
EMBL· GenBank· DDBJ
AKP49212.1
EMBL· GenBank· DDBJ
Genomic DNA
KP770024
EMBL· GenBank· DDBJ
ALD19765.1
EMBL· GenBank· DDBJ
Genomic DNA
JARJGR010000833
EMBL· GenBank· DDBJ
MDF3637271.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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