S5R7Z9 · S5R7Z9_9PROT
- ProteinDNA-directed RNA polymerase subunit beta
- GenerpoB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1362 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Catalytic activity
- RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | DNA-directed RNA polymerase complex | |
Molecular Function | DNA binding | |
Molecular Function | DNA-directed 5'-3' RNA polymerase activity | |
Molecular Function | ribonucleoside binding | |
Biological Process | DNA-templated transcription |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA-directed RNA polymerase subunit beta
- EC number
- Short namesRNAP subunit beta
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Candidatus Profftella
Accessions
- Primary accessionS5R7Z9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-504 | RNA polymerase beta subunit protrusion | ||||
Sequence: ITQLESYYNFLQADIIPSNRKNEGLEAAFRSVFPIHTGLARLEFFSYTLSSPLFDVKECQKRGLTFASSLRVRMRLVILDKESPKSIIKEIKEQEVYMGELPLMTKTGSFIINGTERVVVSQLHRSPGVFFEHDRGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDILFFRIDRRRKMPITVLLKAIGMTPEQILLYFFSFDNFTLHNISGASMNFVAEHLRGEIACFNIIDKNGQIIVPKNKRINYKHIRQIESAGIKKIIVPEDYLIGKVLARNIVDHETNKVIAFANNEITEELLYSFRKANILNIETLYTNDLDHGAYISQTLSIDETRDQITAKTSIYRTMRPGEPPTEDSVNTLFNSLFYDADRYDLSIVGRMKFNRKIGCKKLYGKMTLSNSDILSVIKILVGLRNGHGEIDDIDHLGNRRVRCVGELVENQFRSGLLRVERAVKERLAQSEIENLMPHDLINSKPISS | ||||||
Domain | 153-224 | RNA polymerase Rpb2 | ||||
Sequence: RSPGVFFEHDRGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDILFFRIDRRRKMPITVLLKAIGMTPEQILL | ||||||
Domain | 346-458 | RNA polymerase Rpb2 | ||||
Sequence: DHGAYISQTLSIDETRDQITAKTSIYRTMRPGEPPTEDSVNTLFNSLFYDADRYDLSIVGRMKFNRKIGCKKLYGKMTLSNSDILSVIKILVGLRNGHGEIDDIDHLGNRRVR | ||||||
Domain | 517-584 | RNA polymerase Rpb2 | ||||
Sequence: QFMDQTNALSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAR | ||||||
Domain | 595-660 | DNA-directed RNA polymerase beta subunit external 1 | ||||
Sequence: YRRIENNRITNHVDYLSAIEEGDYVIAQANTTFDSYGLLIDELVYARVAGETILVSSERVQYVDVA | ||||||
Domain | 724-1284 | DNA-directed RNA polymerase subunit 2 hybrid-binding | ||||
Sequence: RGGVVNYVDSMRIVVRVNDNETRIGDVGVDIYNLTKYIRSNQNTNINQRPIVKIGDCVSKHDVIADGTSTDLGELALGQNMLVAFMPWNGYNFEDSILISERVVSNDYYTSIHIEELSVVARDTKLGLEEITRDISSLSESQLSCLDDSGIIYIGSEVVTGDILVGKVTPKGETHLTPEEKLLRAIFGEKASDVKDTSLRVPAGMLGTVIDIQIFTHEGIVRDSRAQQIIHDELQNYDLNLKNQLQIIENDIFQRLEEVLIGKIIHVNTEKEIKITKSYLDNLDKFDWFDIYVDDDTNFFLKRIKNSILERRKKFDLAFKEKKRKLIQGDELPPGVQKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSRILPIEDMPYMADGTTVDIVLNPLGVPSRMNIGQILEVHLGWASRGLGLRLDKMLKEKVDIIKIRKFLDKIYNESGKREELDSLNDKEIMSLVENLKIGIPFATPVFDGANELEIRRMLDLAYPDKISKKLGMTPSKNQVTMYDGRTGEAFDRAVTVGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQ | ||||||
Domain | 1286-1360 | RNA polymerase Rpb2 | ||||
Sequence: GGQRFGEMEVWALEAYGASYILQEMLTVKSDDVNGRTKIYENLVKGDYAINAGMPESFNVLVKEIRSLGIDIDLE |
Sequence similarities
Belongs to the RNA polymerase beta chain family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,362
- Mass (Da)154,313
- Last updated2013-10-16 v1
- Checksum6E7DEBA2D753647D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP003468 EMBL· GenBank· DDBJ | AGS06720.1 EMBL· GenBank· DDBJ | Genomic DNA |