S5R0Z2 · S5R0Z2_9PROT

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site165-167NADP+ (UniProtKB | ChEBI)
Binding site190NADP+ (UniProtKB | ChEBI)
Binding site231NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      SSDC_00745

Organism names

Accessions

  • Primary accession
    S5R0Z2

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-120Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain125-280Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    281
  • Mass (Da)
    30,538
  • Last updated
    2013-10-16 v1
  • Checksum
    B0536AD1C93C2829
MIAKIIDGKKIAKNYFLNITKRVRKLISIGKRPGLAMILVGKNLASKIYIKNKINACKKTGIYSICEKYDSNISESELIHNIHILNKNPLIHGILVQLPLPKHINAIKIIESISSNKDVDGYSIINSGKLMSDLPGFRPCTSYGCIKMIKSTGININGKHAVIIGRSNIVGKPMALLLLKYNATVTVCHSKTKNIKNYTKQADIIITAVGKPNIITGNMIKIGSIIIDVGINRDINNKIRGDVDFSSVLPIAGFISPVPGGVGPMTIAMLLINTVESAEKS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003468
EMBL· GenBank· DDBJ
AGS06842.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp