S5R0Z2 · S5R0Z2_9PROT
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids281 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Candidatus Profftella
Accessions
- Primary accessionS5R0Z2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-120 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | ||||
Sequence: IDGKKIAKNYFLNITKRVRKLISIGKRPGLAMILVGKNLASKIYIKNKINACKKTGIYSICEKYDSNISESELIHNIHILNKNPLIHGILVQLPLPKHINAIKIIESISSNKDVD | ||||||
Domain | 125-280 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | ||||
Sequence: INSGKLMSDLPGFRPCTSYGCIKMIKSTGININGKHAVIIGRSNIVGKPMALLLLKYNATVTVCHSKTKNIKNYTKQADIIITAVGKPNIITGNMIKIGSIIIDVGINRDINNKIRGDVDFSSVLPIAGFISPVPGGVGPMTIAMLLINTVESAEK |
Sequence similarities
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length281
- Mass (Da)30,538
- Last updated2013-10-16 v1
- ChecksumB0536AD1C93C2829
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP003468 EMBL· GenBank· DDBJ | AGS06842.1 EMBL· GenBank· DDBJ | Genomic DNA |