S5R0Y9 · S5R0Y9_9PROT

Function

function

Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron2+ atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Siderophore biosynthesis; enterobactin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site51CoA (UniProtKB | ChEBI)
Binding site59CoA (UniProtKB | ChEBI)
Binding site95-96CoA (UniProtKB | ChEBI)
Binding site118CoA (UniProtKB | ChEBI)
Binding site118Mg2+ (UniProtKB | ChEBI)
Binding site119Mg2+ (UniProtKB | ChEBI)
Binding site164CoA (UniProtKB | ChEBI)
Binding site168CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componententerobactin synthetase complex
Molecular Functionholo-[acyl-carrier-protein] synthase activity
Molecular Functionmagnesium ion binding
Biological Processenterobactin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Enterobactin synthase component D
  • Alternative names
    • 4'-phosphopantetheinyl transferase EntD
    • Enterochelin synthase D

Gene names

    • Name
      dipB
    • ORF names
      SSDC_00720

Organism names

Accessions

  • Primary accession
    S5R0Y9

Proteomes

Subcellular Location

Interaction

Subunit

EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-1054'-phosphopantetheinyl transferase N-terminal
Domain115-1994'-phosphopantetheinyl transferase

Sequence similarities

Belongs to the P-Pant transferase superfamily. EntD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    222
  • Mass (Da)
    25,958
  • Last updated
    2013-10-16 v1
  • Checksum
    504F3211C21F045F
MNIKEDKIIANINNILYKWFPKKTFIETAKIDNYPILPEEKKLVINAVSKRKKEFSTGRWLSRKGLKYFGFPETEILTGYLKNPIWPDKINGSISHDNKLCTVVIMKKIPFLTNIGIDIIYFPKYSNKLKYLESMFVINKNEIDIMDKFGLNIDSSTILFSVKESIIKAISSEINNFIDMRDIKIFYENKKIQFIIQNKKPNVDIFAGISYNYLITAVKIYN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003468
EMBL· GenBank· DDBJ
AGS06837.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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