S5M6I3 · S5M6I3_9TELE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Atheriniformes > Atherinopsidae > Atherinopsinae > Odontesthes

Accessions

  • Primary accession
    S5M6I3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-48Helical
Transmembrane69-93Helical
Transmembrane113-136Helical
Transmembrane148-175Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-187Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    187
  • Mass (Da)
    20,062
  • Last updated
    2013-10-16 v1
  • Checksum
    2523BE83E55A6A70
LIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLSGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAISQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue187

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF254405
EMBL· GenBank· DDBJ
AGR33583.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254406
EMBL· GenBank· DDBJ
AGR33584.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254407
EMBL· GenBank· DDBJ
AGR33585.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254408
EMBL· GenBank· DDBJ
AGR33586.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254409
EMBL· GenBank· DDBJ
AGR33587.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254410
EMBL· GenBank· DDBJ
AGR33588.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254411
EMBL· GenBank· DDBJ
AGR33589.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254412
EMBL· GenBank· DDBJ
AGR33590.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254413
EMBL· GenBank· DDBJ
AGR33591.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254414
EMBL· GenBank· DDBJ
AGR33592.1
EMBL· GenBank· DDBJ
Genomic DNA
KF254416
EMBL· GenBank· DDBJ
AGR33594.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp