S5LQU8 · S5LQU8_HUMAN
- ProteinCellular tumor antigen p53
- GeneTP53
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids115 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 7 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 10 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 69 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 73 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | mitochondrial matrix | |
Cellular Component | PML body | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | metal ion binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | apoptotic process | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCellular tumor antigen p53
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionS5LQU8
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Interaction
Subunit
Binds DNA as a homotetramer.
Structure
Sequence
- Sequence statusFragment
- Length115
- Mass (Da)13,048
- Last updated2013-10-16 v1
- ChecksumA45244BA91E03FBB
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 115 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KC820711 EMBL· GenBank· DDBJ | AGR27806.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820714 EMBL· GenBank· DDBJ | AGR27809.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820715 EMBL· GenBank· DDBJ | AGR27810.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820716 EMBL· GenBank· DDBJ | AGR27811.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820717 EMBL· GenBank· DDBJ | AGR27812.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820718 EMBL· GenBank· DDBJ | AGR27813.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820719 EMBL· GenBank· DDBJ | AGR27814.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820720 EMBL· GenBank· DDBJ | AGR27815.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820721 EMBL· GenBank· DDBJ | AGR27816.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820722 EMBL· GenBank· DDBJ | AGR27817.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820723 EMBL· GenBank· DDBJ | AGR27818.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820725 EMBL· GenBank· DDBJ | AGR27820.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820726 EMBL· GenBank· DDBJ | AGR27821.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820727 EMBL· GenBank· DDBJ | AGR27822.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820728 EMBL· GenBank· DDBJ | AGR27823.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820730 EMBL· GenBank· DDBJ | AGR27825.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820732 EMBL· GenBank· DDBJ | AGR27827.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820733 EMBL· GenBank· DDBJ | AGR27828.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820734 EMBL· GenBank· DDBJ | AGR27829.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820735 EMBL· GenBank· DDBJ | AGR27830.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820736 EMBL· GenBank· DDBJ | AGR27831.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820737 EMBL· GenBank· DDBJ | AGR27832.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820740 EMBL· GenBank· DDBJ | AGR27835.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820741 EMBL· GenBank· DDBJ | AGR27836.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820742 EMBL· GenBank· DDBJ | AGR27837.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820743 EMBL· GenBank· DDBJ | AGR27838.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820744 EMBL· GenBank· DDBJ | AGR27839.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820745 EMBL· GenBank· DDBJ | AGR27840.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820747 EMBL· GenBank· DDBJ | AGR27842.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820748 EMBL· GenBank· DDBJ | AGR27843.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820749 EMBL· GenBank· DDBJ | AGR27844.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820751 EMBL· GenBank· DDBJ | AGR27846.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820753 EMBL· GenBank· DDBJ | AGR27848.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820754 EMBL· GenBank· DDBJ | AGR27849.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820755 EMBL· GenBank· DDBJ | AGR27850.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820757 EMBL· GenBank· DDBJ | AGR27852.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820758 EMBL· GenBank· DDBJ | AGR27853.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820760 EMBL· GenBank· DDBJ | AGR27855.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820761 EMBL· GenBank· DDBJ | AGR27856.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820763 EMBL· GenBank· DDBJ | AGR27858.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820764 EMBL· GenBank· DDBJ | AGR27859.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820765 EMBL· GenBank· DDBJ | AGR27860.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820766 EMBL· GenBank· DDBJ | AGR27861.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820767 EMBL· GenBank· DDBJ | AGR27862.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820768 EMBL· GenBank· DDBJ | AGR27863.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820769 EMBL· GenBank· DDBJ | AGR27864.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820770 EMBL· GenBank· DDBJ | AGR27865.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820771 EMBL· GenBank· DDBJ | AGR27866.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820772 EMBL· GenBank· DDBJ | AGR27867.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820773 EMBL· GenBank· DDBJ | AGR27868.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820774 EMBL· GenBank· DDBJ | AGR27869.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820775 EMBL· GenBank· DDBJ | AGR27870.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820776 EMBL· GenBank· DDBJ | AGR27871.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820777 EMBL· GenBank· DDBJ | AGR27872.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820778 EMBL· GenBank· DDBJ | AGR27873.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820779 EMBL· GenBank· DDBJ | AGR27874.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820780 EMBL· GenBank· DDBJ | AGR27875.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820781 EMBL· GenBank· DDBJ | AGR27876.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820782 EMBL· GenBank· DDBJ | AGR27877.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820783 EMBL· GenBank· DDBJ | AGR27878.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820784 EMBL· GenBank· DDBJ | AGR27879.1 EMBL· GenBank· DDBJ | mRNA | ||
KC820786 EMBL· GenBank· DDBJ | AGR27881.1 EMBL· GenBank· DDBJ | mRNA |