S5LQU8 · S5LQU8_HUMAN

  • Protein
    Cellular tumor antigen p53
  • Gene
    TP53
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

1115102030405060708090100110
TypeIDPosition(s)Description
Binding site7Zn2+ (UniProtKB | ChEBI)
Binding site10Zn2+ (UniProtKB | ChEBI)
Binding site69Zn2+ (UniProtKB | ChEBI)
Binding site73Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentendoplasmic reticulum
Cellular Componentmitochondrial matrix
Cellular ComponentPML body
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processapoptotic process
Biological Processpositive regulation of DNA-templated transcription
Biological Processrhythmic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cellular tumor antigen p53

Gene names

    • Name
      TP53

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    S5LQU8

Subcellular Location

Keywords

PTM/Processing

Keywords

Proteomic databases

Interaction

Subunit

Binds DNA as a homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-114p53 DNA-binding

Sequence similarities

Belongs to the p53 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    115
  • Mass (Da)
    13,048
  • Last updated
    2013-10-16 v1
  • Checksum
    A45244BA91E03FBB
TEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue115

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC820711
EMBL· GenBank· DDBJ
AGR27806.1
EMBL· GenBank· DDBJ
mRNA
KC820714
EMBL· GenBank· DDBJ
AGR27809.1
EMBL· GenBank· DDBJ
mRNA
KC820715
EMBL· GenBank· DDBJ
AGR27810.1
EMBL· GenBank· DDBJ
mRNA
KC820716
EMBL· GenBank· DDBJ
AGR27811.1
EMBL· GenBank· DDBJ
mRNA
KC820717
EMBL· GenBank· DDBJ
AGR27812.1
EMBL· GenBank· DDBJ
mRNA
KC820718
EMBL· GenBank· DDBJ
AGR27813.1
EMBL· GenBank· DDBJ
mRNA
KC820719
EMBL· GenBank· DDBJ
AGR27814.1
EMBL· GenBank· DDBJ
mRNA
KC820720
EMBL· GenBank· DDBJ
AGR27815.1
EMBL· GenBank· DDBJ
mRNA
KC820721
EMBL· GenBank· DDBJ
AGR27816.1
EMBL· GenBank· DDBJ
mRNA
KC820722
EMBL· GenBank· DDBJ
AGR27817.1
EMBL· GenBank· DDBJ
mRNA
KC820723
EMBL· GenBank· DDBJ
AGR27818.1
EMBL· GenBank· DDBJ
mRNA
KC820725
EMBL· GenBank· DDBJ
AGR27820.1
EMBL· GenBank· DDBJ
mRNA
KC820726
EMBL· GenBank· DDBJ
AGR27821.1
EMBL· GenBank· DDBJ
mRNA
KC820727
EMBL· GenBank· DDBJ
AGR27822.1
EMBL· GenBank· DDBJ
mRNA
KC820728
EMBL· GenBank· DDBJ
AGR27823.1
EMBL· GenBank· DDBJ
mRNA
KC820730
EMBL· GenBank· DDBJ
AGR27825.1
EMBL· GenBank· DDBJ
mRNA
KC820732
EMBL· GenBank· DDBJ
AGR27827.1
EMBL· GenBank· DDBJ
mRNA
KC820733
EMBL· GenBank· DDBJ
AGR27828.1
EMBL· GenBank· DDBJ
mRNA
KC820734
EMBL· GenBank· DDBJ
AGR27829.1
EMBL· GenBank· DDBJ
mRNA
KC820735
EMBL· GenBank· DDBJ
AGR27830.1
EMBL· GenBank· DDBJ
mRNA
KC820736
EMBL· GenBank· DDBJ
AGR27831.1
EMBL· GenBank· DDBJ
mRNA
KC820737
EMBL· GenBank· DDBJ
AGR27832.1
EMBL· GenBank· DDBJ
mRNA
KC820740
EMBL· GenBank· DDBJ
AGR27835.1
EMBL· GenBank· DDBJ
mRNA
KC820741
EMBL· GenBank· DDBJ
AGR27836.1
EMBL· GenBank· DDBJ
mRNA
KC820742
EMBL· GenBank· DDBJ
AGR27837.1
EMBL· GenBank· DDBJ
mRNA
KC820743
EMBL· GenBank· DDBJ
AGR27838.1
EMBL· GenBank· DDBJ
mRNA
KC820744
EMBL· GenBank· DDBJ
AGR27839.1
EMBL· GenBank· DDBJ
mRNA
KC820745
EMBL· GenBank· DDBJ
AGR27840.1
EMBL· GenBank· DDBJ
mRNA
KC820747
EMBL· GenBank· DDBJ
AGR27842.1
EMBL· GenBank· DDBJ
mRNA
KC820748
EMBL· GenBank· DDBJ
AGR27843.1
EMBL· GenBank· DDBJ
mRNA
KC820749
EMBL· GenBank· DDBJ
AGR27844.1
EMBL· GenBank· DDBJ
mRNA
KC820751
EMBL· GenBank· DDBJ
AGR27846.1
EMBL· GenBank· DDBJ
mRNA
KC820753
EMBL· GenBank· DDBJ
AGR27848.1
EMBL· GenBank· DDBJ
mRNA
KC820754
EMBL· GenBank· DDBJ
AGR27849.1
EMBL· GenBank· DDBJ
mRNA
KC820755
EMBL· GenBank· DDBJ
AGR27850.1
EMBL· GenBank· DDBJ
mRNA
KC820757
EMBL· GenBank· DDBJ
AGR27852.1
EMBL· GenBank· DDBJ
mRNA
KC820758
EMBL· GenBank· DDBJ
AGR27853.1
EMBL· GenBank· DDBJ
mRNA
KC820760
EMBL· GenBank· DDBJ
AGR27855.1
EMBL· GenBank· DDBJ
mRNA
KC820761
EMBL· GenBank· DDBJ
AGR27856.1
EMBL· GenBank· DDBJ
mRNA
KC820763
EMBL· GenBank· DDBJ
AGR27858.1
EMBL· GenBank· DDBJ
mRNA
KC820764
EMBL· GenBank· DDBJ
AGR27859.1
EMBL· GenBank· DDBJ
mRNA
KC820765
EMBL· GenBank· DDBJ
AGR27860.1
EMBL· GenBank· DDBJ
mRNA
KC820766
EMBL· GenBank· DDBJ
AGR27861.1
EMBL· GenBank· DDBJ
mRNA
KC820767
EMBL· GenBank· DDBJ
AGR27862.1
EMBL· GenBank· DDBJ
mRNA
KC820768
EMBL· GenBank· DDBJ
AGR27863.1
EMBL· GenBank· DDBJ
mRNA
KC820769
EMBL· GenBank· DDBJ
AGR27864.1
EMBL· GenBank· DDBJ
mRNA
KC820770
EMBL· GenBank· DDBJ
AGR27865.1
EMBL· GenBank· DDBJ
mRNA
KC820771
EMBL· GenBank· DDBJ
AGR27866.1
EMBL· GenBank· DDBJ
mRNA
KC820772
EMBL· GenBank· DDBJ
AGR27867.1
EMBL· GenBank· DDBJ
mRNA
KC820773
EMBL· GenBank· DDBJ
AGR27868.1
EMBL· GenBank· DDBJ
mRNA
KC820774
EMBL· GenBank· DDBJ
AGR27869.1
EMBL· GenBank· DDBJ
mRNA
KC820775
EMBL· GenBank· DDBJ
AGR27870.1
EMBL· GenBank· DDBJ
mRNA
KC820776
EMBL· GenBank· DDBJ
AGR27871.1
EMBL· GenBank· DDBJ
mRNA
KC820777
EMBL· GenBank· DDBJ
AGR27872.1
EMBL· GenBank· DDBJ
mRNA
KC820778
EMBL· GenBank· DDBJ
AGR27873.1
EMBL· GenBank· DDBJ
mRNA
KC820779
EMBL· GenBank· DDBJ
AGR27874.1
EMBL· GenBank· DDBJ
mRNA
KC820780
EMBL· GenBank· DDBJ
AGR27875.1
EMBL· GenBank· DDBJ
mRNA
KC820781
EMBL· GenBank· DDBJ
AGR27876.1
EMBL· GenBank· DDBJ
mRNA
KC820782
EMBL· GenBank· DDBJ
AGR27877.1
EMBL· GenBank· DDBJ
mRNA
KC820783
EMBL· GenBank· DDBJ
AGR27878.1
EMBL· GenBank· DDBJ
mRNA
KC820784
EMBL· GenBank· DDBJ
AGR27879.1
EMBL· GenBank· DDBJ
mRNA
KC820786
EMBL· GenBank· DDBJ
AGR27881.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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