S4Y1T5 · S4Y1T5_SORCE

Function

function

Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17-22ATP (UniProtKB | ChEBI)
Binding site21Mg2+ (UniProtKB | ChEBI)
Binding site39substrate
Binding site63substrate
Binding site86substrate
Binding site123ATP (UniProtKB | ChEBI)
Binding site143substrate
Binding site279-283NAD+ (UniProtKB | ChEBI)
Binding site303-304NAD+ (UniProtKB | ChEBI)
Binding site316NAD+ (UniProtKB | ChEBI)
Binding site325NAD+ (UniProtKB | ChEBI)
Binding site358Zn2+ (UniProtKB | ChEBI)
Binding site421Zn2+ (UniProtKB | ChEBI)
Binding site438Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-dehydroquinate synthase activity
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionshikimate kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Shikimate kinase
  • EC number
  • Short names
    SK
  • Recommended name
    3-dehydroquinate synthase
  • EC number
  • Short names
    DHQS

Gene names

    • Name
      aroK
    • Synonyms
      aroB
    • ORF names
      SCE1572_28885

Organism names

Accessions

  • Primary accession
    S4Y1T5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain242-4983-dehydroquinate synthase

Sequence similarities

Belongs to the shikimate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    536
  • Mass (Da)
    55,096
  • Last updated
    2013-10-16 v1
  • Checksum
    FA68A928C8D7FACA
MALPPDAPPLLLTGFMGTGKSTVGRIAAARAGLPFVDLDDAIAAEAGEGVPSLFAARGEAGFRALEAATLRRLLATRGPRVIALGGGALVDPALRLEALERGCVVALSATPRTIAARTPGGGRPLLDGAPDREARIRELLAARASVYAEAHARVVTDGVSPADVAARVLRAYADRPLFVPLGDKSYAVRIAADGAASAADAVAALSPSSVFVVTDENVSRLWGAPLLDALAAHAKPAAAVTVLTPGEEHKRLAAVEAALTAMLDAGADRDAVVLAHGGGVVTDIGGFAASTLLRGVRWVAAPTTLLSMVDASVGGKTGVDLGPAKNAVGTFHQPSAVVASPAALATETDRAFRSGLAEVVKSACIADPELHALLEREADRVLARDPGLLAELIRRSIAVKAAIVARDERESGDRALLNFGHTLGHALEAEGGFVRLAHGEAVSLGMVAMLRVGCSLGVTDRAAADRVVRLLARLGLPTRIEDEPVSAALRFLSLDKKRRGSSVRTVLMRDIGSTFVEPMPLDRLSSLLERAAAGAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003969
EMBL· GenBank· DDBJ
AGP38135.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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