S4R255 · S4R255_MOUSE
- ProteinNitric oxide synthase
- GeneNos1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1425 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions.
Catalytic activity
- H+ + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP+ + 2 nitric oxideThis reaction proceeds in the forward direction.
CHEBI:15378 + 2 CHEBI:32682 + 3 CHEBI:57783 + 4 CHEBI:15379 = 4 CHEBI:15377 + 2 CHEBI:57743 + 3 CHEBI:58349 + 2 CHEBI:16480
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FAD.
Note: Binds 1 FMN.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | dendritic spine | |
Cellular Component | sarcolemma | |
Molecular Function | calmodulin binding | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | FMN binding | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | nitric-oxide synthase activity | |
Biological Process | nitric oxide biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNitric oxide synthase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionS4R255
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane, sarcolemma ; Peripheral membrane protein
PTM/Processing
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-99 | PDZ | ||||
Sequence: SVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRG | ||||||
Compositional bias | 114-143 | Polar residues | ||||
Sequence: DGTPKTIRVTQPLGTPTKAVDLSRQPSASK | ||||||
Region | 114-174 | Disordered | ||||
Sequence: DGTPKTIRVTQPLGTPTKAVDLSRQPSASKDQPLAVDRVPGPSNGPQHAQGRGQGAGSVSQ | ||||||
Compositional bias | 160-174 | Polar residues | ||||
Sequence: QHAQGRGQGAGSVSQ | ||||||
Compositional bias | 271-294 | Polar residues | ||||
Sequence: NNPYSENEQSPASGKQSPTKNGSP | ||||||
Region | 271-298 | Disordered | ||||
Sequence: NNPYSENEQSPASGKQSPTKNGSPSRCP | ||||||
Domain | 755-935 | Flavodoxin-like | ||||
Sequence: ATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVF | ||||||
Domain | 990-1237 | FAD-binding FR-type | ||||
Sequence: KRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLP |
Sequence similarities
Belongs to the NOS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,425
- Mass (Da)160,052
- Last updated2013-09-18 v1
- ChecksumE5B41BFC7274BE5E
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 114-143 | Polar residues | ||||
Sequence: DGTPKTIRVTQPLGTPTKAVDLSRQPSASK | ||||||
Compositional bias | 160-174 | Polar residues | ||||
Sequence: QHAQGRGQGAGSVSQ | ||||||
Compositional bias | 271-294 | Polar residues | ||||
Sequence: NNPYSENEQSPASGKQSPTKNGSP |
Keywords
- Technical term