S3CMI9 · S3CMI9_OPHP1

Function

function

Maintains high levels of reduced glutathione in the cytosol.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, active site.

156750100150200250300350400450500550
TypeIDPosition(s)Description
Binding site151FAD (UniProtKB | ChEBI)
Binding site285-292NAD+ (UniProtKB | ChEBI)
Binding site375NAD+ (UniProtKB | ChEBI)
Binding site416FAD (UniProtKB | ChEBI)
Active site556Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionglutathione-disulfide reductase (NADPH) activity
Molecular FunctionNADP binding
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processglutathione metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione reductase
  • EC number

Gene names

    • ORF names
      F503_00425

Organism names

Accessions

  • Primary accession
    S3CMI9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond142↔147Redox-active

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain105-431FAD/NAD(P)-binding
Domain454-565Pyridine nucleotide-disulphide oxidoreductase dimerisation

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    567
  • Mass (Da)
    60,839
  • Last updated
    2013-09-18 v1
  • Checksum
    E5583FD913AC4381
MSSAMLRPHRLVLKVRHSPSISCYPYSAASYPSSASSSTPPIASSKPMRAFSSTARASNSLSSTLSSALSSAPISSSTSTSRLASLSRHLSSSARTMAPISKETDYLVIGGGSGGLASARMAASKFGIKATIIEGSRLGGTCVNVGCVPKKVTFNAAAIAEALHDAKAYGFSVEQTKPFDWTTFKHKRDAYIERLNGIYARNLNNDKVENVHGWARFTGPNEVTVALDEADEAGNKEVVIRSKKILIAVGGRPSDPPSIPGAEHGINSNGFFDIETQPKKVAIVGAGYIAVEFAGMFNALGTETHLFIRHKTFLRSFDPIIQDGVTDNYEKLGVKLHRETQLTRVDKDATTGKLTLHYGSGETVTDVDHLIWAVGRTPLTKDIGLDLAGVKLTDKGYIIADKLQETSAEGIYALGDVTGPVELTPVAIAAGRRLAHRLFGGPEFSNYHMDYTNVPSVVFSHPEVGSIGLTEPQAIEQYGKDNIKVYKTNFTAMYYAMMEPEEKRPTAYKLVTAGKEEKVVGLHIMGLGSGEMLQGFGVAIKMGATKKDFDSVVAIHPTSAEELVTLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE148150
EMBL· GenBank· DDBJ
EPE07703.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp