S3CMI9 · S3CMI9_OPHP1
- ProteinGlutathione reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids567 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Maintains high levels of reduced glutathione in the cytosol.
Catalytic activity
- 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | glutathione-disulfide reductase (NADPH) activity | |
Molecular Function | NADP binding | |
Biological Process | cell redox homeostasis | |
Biological Process | cellular response to oxidative stress | |
Biological Process | glutathione metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione reductase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Ophiostomatales > Ophiostomataceae > Ophiostoma
Accessions
- Primary accessionS3CMI9
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 142↔147 | Redox-active | ||||
Sequence: CVNVGC |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 105-431 | FAD/NAD(P)-binding | ||||
Sequence: DYLVIGGGSGGLASARMAASKFGIKATIIEGSRLGGTCVNVGCVPKKVTFNAAAIAEALHDAKAYGFSVEQTKPFDWTTFKHKRDAYIERLNGIYARNLNNDKVENVHGWARFTGPNEVTVALDEADEAGNKEVVIRSKKILIAVGGRPSDPPSIPGAEHGINSNGFFDIETQPKKVAIVGAGYIAVEFAGMFNALGTETHLFIRHKTFLRSFDPIIQDGVTDNYEKLGVKLHRETQLTRVDKDATTGKLTLHYGSGETVTDVDHLIWAVGRTPLTKDIGLDLAGVKLTDKGYIIADKLQETSAEGIYALGDVTGPVELTPVAIAAG | ||||||
Domain | 454-565 | Pyridine nucleotide-disulphide oxidoreductase dimerisation | ||||
Sequence: VPSVVFSHPEVGSIGLTEPQAIEQYGKDNIKVYKTNFTAMYYAMMEPEEKRPTAYKLVTAGKEEKVVGLHIMGLGSGEMLQGFGVAIKMGATKKDFDSVVAIHPTSAEELVT |
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length567
- Mass (Da)60,839
- Last updated2013-09-18 v1
- ChecksumE5583FD913AC4381
Keywords
- Technical term