S3CM74 · S3CM74_OPHP1

Function

function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

139850100150200250300350
Type
IDPosition(s)Description
Binding site19Zn2+ (UniProtKB | ChEBI); catalytic
Binding site21Zn2+ (UniProtKB | ChEBI); catalytic
Binding site252Zn2+ (UniProtKB | ChEBI); catalytic
Active site255Proton donor
Site276Important for catalytic activity
Binding site333Zn2+ (UniProtKB | ChEBI); catalytic
Binding site334substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionadenine deaminase activity
Molecular Functionzinc ion binding
Biological Processadenine catabolic process
Biological Processhypoxanthine salvage
Biological Processnucleotide metabolic process
Biological Processpurine ribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenine deaminase
  • EC number
  • Short names
    ADE
  • Alternative names
    • Adenine aminohydrolase
      (AAH
      )

Gene names

    • Name
      AAH1
    • ORF names
      F503_00340

Organism names

Accessions

  • Primary accession
    S3CM74

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-163Adenosine deaminase
Domain204-387Adenosine deaminase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    398
  • Mass (Da)
    43,659
  • Last updated
    2013-09-18 v1
  • MD5 Checksum
    7938F9DF0A70876B7629199594C9400B
MCHHKLHPLLAALPKCEHHMHVEGSLSPELLFELAARNGVTLPVAEDDSFASTEALYARYARFTSLDDFLHYYYIGMSVLQTAADFETLAMEYFKKAHAANVRHAEIFFDPQVHLARGISLADVVRGLRAASLRATAELGGMTSLLIPCLLRHLPVADSGELVSQLREGYWAGGDEQKQEETVVNALEAAFEGDKDAVSLRGALAGLGLCSSERDLPPTLWREVYQEARRHSVSSAEKPTLARRGATRLTAHAGEEGPAEYITLALDHLGAQRIDHGVAAATDPAVMERLAREQILLTVCPISNVCLRVTKSVKEVPIRTFLDANVPFSINSDDPAYFGGYIQENYCAVQEAHDLSVDDWATIVRNSIRLSWCDDARKQVVLDEIDSVLAAWAAGTLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE148150
EMBL· GenBank· DDBJ
EPE07618.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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