S3CBF6 · S3CBF6_OPHP1

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      F503_01851

Organism names

Accessions

  • Primary accession
    S3CBF6

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane66-86Helical
Transmembrane107-126Helical
Transmembrane138-157Helical
Transmembrane230-252Helical
Transmembrane284-308Helical
Transmembrane328-349Helical
Transmembrane356-377Helical
Transmembrane383-401Helical
Transmembrane422-439Helical
Transmembrane451-476Helical
Transmembrane513-534Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain72-473Major facilitator superfamily (MFS) profile

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    544
  • Mass (Da)
    60,177
  • Last updated
    2013-09-18 v1
  • Checksum
    3AB4DA73DD0C5FA7
MASQETRQPETVAVVETSKDISQQISNEKSVEASLETSKETHQVTIEAADDAASISSSEGKPQPPWQWKLIAVILLTLIRFGGAWGSGIISPMKSTLKKKLKINNTMYSLLDASDSFIKTVLILLTGYVTDRYGGENILLYGNAVYSVGSVLMAGAAQMRNYKFFIVARIVMSLGDCSTQIAQYQVFSAWFAPSNGFASTLGIELMFNKLGAFAGSGTSNVINSNIGFSWVYWIAFIVNVFTNFCCYAFYWFMRRSEGKYSDVRDPATGGRLKKRSRKLNFKKVLAMPWSFWVVMGYGMFTTITIIIFNSNATEFAEQRFKISAVKAGWYTTLARDAGFVLIPLLAFVIDFFGQRIILMAISSFGIFTAMVLVNYASTVTGTAAAFGIYAVATTFSPLSIIDSIRVTLTEQVDFGTAYALKILVNNCLDVIVAIVAGVIQDRDDNSYDNVVILYLALSSASVVMCINMIAFGYFTVDIGMLQWTRKQRIARGDKIVDRDRRTRAEDAPKNRRLSTVLFSCIMVLMVGAWVAYIWGAATGNNYDS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE148166
EMBL· GenBank· DDBJ
EPE03593.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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