S3C7P9 · S3C7P9_OPHP1

Function

function

Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Catalytic activity

Features

Showing features for site, binding site, active site.

151750100150200250300350400450500
TypeIDPosition(s)Description
Site181Interaction with histone H4 N-terminus
Binding site263-265acetyl-CoA (UniProtKB | ChEBI)
Active site298Proton donor/acceptor
Binding site301acetyl-CoA (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionhistone binding
Molecular Functionhistone H4 acetyltransferase activity
Biological ProcessDNA repair
Biological Processsubtelomeric heterochromatin formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone acetyltransferase type B catalytic subunit
  • EC number

Gene names

    • ORF names
      F503_04424

Organism names

Accessions

  • Primary accession
    S3C7P9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain8-165Histone acetyl transferase HAT1 N-terminal
Region210-212Interaction with histone H4 N-terminus
Region381-414Disordered
Region486-517Disordered

Sequence similarities

Belongs to the HAT1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    517
  • Mass (Da)
    58,045
  • Last updated
    2013-09-18 v1
  • Checksum
    B86FFD5BD7F0A356
MEHSYDEWVSNANEAVEISLVQPAPSGLRSIASFNPKFTYSIFGNEETIFGYQDLKISLRYHASDMRPNLHVSSSKKMKVVGENEPVDIPAILKDFLPPVAFQKASEFEDAVKQTPAADYTPPGERIKEFYSSDGRYEIWKGTLSDPAVKQLVSRVQIMVPFFIEGGTFIGSDDSESADRWTIFFLYRTRQSSGSADRYEHEFAGYSTVYRFLLPLGAATPPRTVANGESAAETAELQLPASDSGEPEFSLATLPCRSRISQFIILPPFQGKGNAGRLYSTIFDEYLAEPQTTEITVEDPNEAFDDLRDIADLKFLSRLPAFTKTVSINKTVQIPRTGPSPNNIVDASALDTLRYQAKIAPRQFNRAVEMYLMQKLAPAVRPTLEGDEDEEEEEEDERAAARTAANGKGKAPAMPALATKEQQHEYRLWRMFVKQRLYRHNKEILGQLDRSQRIEKLEETLRSVELEYARILSMFESRTKLATVEEAQSTATKRKLTTEAGAEVAQNGSKKARIEDA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE148148
EMBL· GenBank· DDBJ
EPE08837.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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