R9U320 · R9U320_BOTFB

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Ordered locus names
      BC1G_20024

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    R9U320

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-81Helical
Transmembrane96-116Helical
Transmembrane137-158Helical
Transmembrane192-216Helical
Transmembrane228-257Helical
Transmembrane304-321Helical
Transmembrane328-350Helical
Transmembrane370-394Helical
Transmembrane406-426Helical
Transmembrane446-468Helical
Transmembrane489-508Helical
Transmembrane528-550Helical

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain42-604Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    606
  • Mass (Da)
    67,278
  • Last updated
    2013-09-18 v1
  • Checksum
    2B0D952129029022
MEVSQPHRSFVLNNINISLKEETVSNRPAVDSNLSVLRANISLWTERWFLSSNAKDIGTLYLIFALFSGLLGTAFSVLIRLELSGPGVQYIADNQLYNAIITAHAILMIFFMPNGYNKMNFLLPLLVGGPDMAFPRLNNISFWLLPPSLILFLFASGIENGAGTGWTLNGYQYNCYPPLSGVQSHSGPSVDLAIFALHLSGIIRNIGCIFVITTILNMRAPGISLHKLALFGWAVVVTAVLLLLSLPVLAGAITMVLTDRNFNTSFFEAAGGGDPILYQHLFSRLVFEDYFIFSTNGFFGHPEVYILIIPGFGIISTVISASSNKSVFGYLGMVYAMMSIGVLGFVVWSWEYLLTILHHMYTVGLDVDTRAYFTAATLIIAVPTGIKIFSWLATCYGGSLQLTPSMLFALGFVFMFTIGGLMNIFLQVSGVVLANASLDIAFHDTYYVVAHFHYVLSMGAVFALYSAWYFWIPKILGLDYNKMLGKAHFWILFIGIHLKFLDLQHFLGLQGMPRRISDYPDAFAGWNLISSFGSIISVVATVLFLHIVYVQLVEGKATTRYPWLTPQFYSDSLQTLLNRSYNSLEWALTSPPKPHAFVSLPLQSRL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC832409
EMBL· GenBank· DDBJ
AGN49004.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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