R9S523 · R9S523_BURTH
- ProteinTstGH
- GenetstGH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids4855 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + H+ + NADH
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 77 | Proton acceptor; for dehydratase activity | ||||
Sequence: H | ||||||
Active site | 278 | Proton donor; for dehydratase activity | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | 3-hydroxyacyl-CoA dehydrogenase activity | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Molecular Function | fatty acid synthase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | N,N-dimethylaniline monooxygenase activity | |
Molecular Function | NADP binding | |
Molecular Function | phosphopantetheine binding | |
Biological Process | DIM/DIP cell wall layer assembly | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > pseudomallei group
Accessions
- Primary accessionR9S523
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 45-192 | N-terminal hotdog fold | ||||
Sequence: HAPPADAARRANGGARALLYCALTGREFFLADHRVDGVRVLPAAAYFEFVRAALRHAGFASAEGFALTHVSLERPLAIDGDGDDADRLLVVELLADARGRIGFTLASTGRALAEVAPCLDASPRAALAADAGLSVHCTGVYLPEPMPG | ||||||
Domain | 45-362 | PKS/mFAS DH | ||||
Sequence: HAPPADAARRANGGARALLYCALTGREFFLADHRVDGVRVLPAAAYFEFVRAALRHAGFASAEGFALTHVSLERPLAIDGDGDDADRLLVVELLADARGRIGFTLASTGRALAEVAPCLDASPRAALAADAGLSVHCTGVYLPEPMPGVDAGTEAETGADTEADAPDARSGAPVYDADACYRFLAARGFEYGARQRALQRIVLHGPHRLHADLALPAPLAASLPAMWLHPSLLDGALQAAAGFYLAEPVGAEPGLPFAVDEIAVWRACEPRMRARVTRHAADAGATTRLDVALYGTDGRLCVALKGLTSRTRRARASR | ||||||
Region | 192-214 | Disordered | ||||
Sequence: GVDAGTEAETGADTEADAPDARS | ||||||
Region | 214-362 | C-terminal hotdog fold | ||||
Sequence: SGAPVYDADACYRFLAARGFEYGARQRALQRIVLHGPHRLHADLALPAPLAASLPAMWLHPSLLDGALQAAAGFYLAEPVGAEPGLPFAVDEIAVWRACEPRMRARVTRHAADAGATTRLDVALYGTDGRLCVALKGLTSRTRRARASR | ||||||
Domain | 835-911 | Carrier | ||||
Sequence: ALRGAAARLLQRIVAGELKLPPEQLRTDQPLDQYGIDSVDMMKATRELEKTFGILPKTLFFQYPSIDELAVHFAERH | ||||||
Domain | 979-1413 | Ketosynthase family 3 (KS3) | ||||
Sequence: RSDIAIIGLSGRYPRSADVAEFWDNLAGGVDAVREIPAERWDWRAFHRDGDGHRPGAHASRWGGFIDGVDEFDPLFFNISPSEAEIMDPQERLFLQHAWAALEDAGYSRGRLARERREREAAGIGTGAGETGVYVGVMYSEYIQCANNDPERLVGSSYASIANRVSYALDLRGPSLAIDTMCSSSLTCLHLACGELASGGIGMALVGGVNLNLHPNKYHLLSRGRFVSPRGRCHSFGADGDGYVPSEGVGVVCVKRLADAQRDGDPIYAVIRGSAINHGGKSQGYSVPQPQRQQDVIRQALKQAQVDARAISYVEAHGTGTSLGDPIEIAGLAGAFSRDTADTQFCAIGSVKSNVGHCEAAAGMAALTKVIGQMRAGELFPSLHAQRLNPHIDFAASPFAVVRERRPWAGVAGRRIAAVSSFGAGGSNAHFVLQD | ||||||
Domain | 2080-2153 | Carrier | ||||
Sequence: ERVTGRLRELLGRLCKLSPQRIDPRAQFENYGVDSVRVIHLQQALGKHYPGIGSALLYEHTTLASLAAHLVAQH | ||||||
Region | 2160-2185 | Disordered | ||||
Sequence: WAGEPEHADAPAAPEAEPPRATGGDN | ||||||
Domain | 2204-2635 | Ketosynthase family 3 (KS3) | ||||
Sequence: EDLIAIIGIAGRYPKAANLAEYWRNLAGGVDCIDEIPAERWSLDGFYVADKDEASRTGRSYSKWGGFLDGFADFDPQFFSIAPRDAWLMDPQERLFLQCAWEALEDAGYSREALVERHRARAGVFVGATKTGFELYGPQFWRQNKAFLPRTSFGSIANRVSYCLDLTGPSLAIDTMCSSSLVAIHEACERLRRGDCDIAIAGGVNLYLHPANYVALCSGHMLSPEGRCRSFGAGADGFVPGEGVGAVILKPLALARRDGDAIHAVIRASGINHSGKTHGYMVPSPASQQALIRLTLARAGCDAASIGYLEAHGTGTALGDPIEFRGLVQAFGERGAGVQCALGSVKSNIGHLEAAAGIAALTKVVLQLRHRKLVPTLHAAELNPEIALDGSGFVMCDMLRDWTPQPGADAPLRAGISSFGAGGVNAHLIVEQ | ||||||
Region | 2858-2889 | Disordered | ||||
Sequence: AEAARSRSAAHSPQPDSTARRAPAAEPLIARR | ||||||
Domain | 3382-3459 | Carrier | ||||
Sequence: TPARDLAALLKSTLAAEIQLSADELDDEAGFVDLGLDSVTAVTWARTLGRALSIELTPAHVYQYPSVAKLLAYLREAT | ||||||
Domain | 3499-3573 | Carrier | ||||
Sequence: IAIVEIVRQTLAAELQLDAQDIDAHASFVDMGLDSVTAVTWARKLHERLAVDLSPTQLYQHPNVAALCAHLSDAG | ||||||
Region | 3576-3644 | Disordered | ||||
Sequence: AGPDAAAHAAADRAARTAASEPASRPALQPAPPSIAAQAPALATVQAPPAVGSTPEPPPTPADAPRRAA | ||||||
Domain | 3648-4071 | Ketosynthase family 3 (KS3) | ||||
Sequence: RVDIAIIGMAGRFPGAADLDAFWRNLVEGRDSIVEVPPHRWSLDRHYDPDPQAKGKTYSRWIGLLDDADAFDAEFFGISPREAEHMDPQQRVFMENCWHAIEHAGYNPFSLATQRTGLFVGCATGDYADLGRRDEAGAQSFMGGASSILSARMPYFLNLDGPCLAIDTACSSALVAVNEACNSLLLGNCDLAIAGGVCVMAGPTLHILSSKAGMLSPTGRCRTFDGAADGFVPGEGVGTVLLRRLDEALAAGDTIHGVIRGWGINQDGRTNGITAPNPDAQRRLASGVYRRFGIDPKRIMMAEAHGTGTKLGDPIEVRALTEAFREFDAGTGYCAIGSVKSNIGHLALAAGIAGLLKVVLSLRHRTIPPTLHCESVNEHIDLARSPFHVPRVAQAWRTADGAPRMACVSSFGFSGTNAHMVVEQ | ||||||
Region | 4803-4826 | Disordered | ||||
Sequence: DDGAEPPGGEPAAERAPSPGSPEW |
Sequence similarities
Belongs to the enoyl-CoA hydratase/isomerase family.