Wild-type V protein of Urabe AM9 strain of mumps virus may be more efficient than its mutant to inactivate both the interferon signaling pathway and antiviral response due to differences in their finest molecular interaction with STAT proteins.
STAT2 and IRF-1 comppete at binding interferon-stimulated response elements (ISREs) located on the retinoic acid-induced gene G (RIG-G) promoter in RIG-G.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator); Data show that STAT2*C related genotypes and alleles are associated with asthma susceptibilities and pathogenesis.
presence of intracellular HCV antigens led to transcriptional and protein expression of IL-8 (CXCL-8) and impaired interferon induction of signal transducers and activators of transcription 1 (STAT1) serine and tyrosine and STAT2 tyrosine phosphorylation
Data reveal the existence of a collection of GAS-regulated target genes whose expression is interferon-inducible and independent of ISGF3 but highly dependent on the STAT2 DNA binding domain.
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