R9PXY3 · R9PXY3_RAT
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- GenePlcb1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1173 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionR9PXY3
Proteomes
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 469-534 | Disordered | ||||
Sequence: KSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEA | ||||||
Compositional bias | 480-500 | Polar residues | ||||
Sequence: KKLSEQASNTYSDSSSVFEPS | ||||||
Compositional bias | 507-521 | Acidic residues | ||||
Sequence: ADTESDDDDDDDDCK | ||||||
Domain | 540-656 | PI-PLC Y-box | ||||
Sequence: MSNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMR | ||||||
Domain | 656-784 | C2 | ||||
Sequence: RRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPL | ||||||
Region | 834-891 | Disordered | ||||
Sequence: DEEEVKKEADPGETSSEAPSETRTTPAENGVNHTATLAPKPPSQAPHSQPAPGSVKAP | ||||||
Compositional bias | 848-875 | Polar residues | ||||
Sequence: SSEAPSETRTTPAENGVNHTATLAPKPP | ||||||
Compositional bias | 967-982 | Basic and acidic residues | ||||
Sequence: EKSAKKDSKKKSEPSS | ||||||
Region | 967-989 | Disordered | ||||
Sequence: EKSAKKDSKKKSEPSSPDHGSSA | ||||||
Region | 1070-1095 | Disordered | ||||
Sequence: KKMDKKRQEKITEAKSKDKSQMEEEK | ||||||
Region | 1131-1173 | Disordered | ||||
Sequence: IRQQILDEKPKGEGSSSVLSESCHEDPSVPPNFTPPNPQALKW |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,173
- Mass (Da)133,393
- Last updated2022-05-25 v3
- Checksum0979B9733570EC34
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P10687 | PLCB1_RAT | Plcb1 | 1216 | ||
F1M084 | F1M084_RAT | Plcb1 | 1135 | ||
A0A8I6A2P4 | A0A8I6A2P4_RAT | Plcb1 | 1124 | ||
A0A8I5ZP96 | A0A8I5ZP96_RAT | Plcb1 | 1032 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 480-500 | Polar residues | ||||
Sequence: KKLSEQASNTYSDSSSVFEPS | ||||||
Compositional bias | 507-521 | Acidic residues | ||||
Sequence: ADTESDDDDDDDDCK | ||||||
Compositional bias | 848-875 | Polar residues | ||||
Sequence: SSEAPSETRTTPAENGVNHTATLAPKPP | ||||||
Compositional bias | 967-982 | Basic and acidic residues | ||||
Sequence: EKSAKKDSKKKSEPSS |
Keywords
- Technical term