R9CCB3 · R9CCB3_9CLOT

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site119(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site123-125(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site227Plays an important role in substrate specificity
Binding site242(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site351-353(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      A500_06471

Organism names

Accessions

  • Primary accession
    R9CCB3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue228N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-382Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    411
  • Mass (Da)
    45,030
  • Last updated
    2013-07-24 v1
  • Checksum
    733838A23CF5CB84
MNFENISKEDKVIYNLIEKELKRQQDGIELIASENFASKAVMEAMGSFLTNKYAEGYPNKRYYGGCHVVDEIEAIAIERAKELFGAEHANVQPHSGSQANMAVYLAVLEHGDTVLGMNLSHGGHLTHGSPVNFSGKLFNFVSYGVDAESETIDYDIVREMAIKNKPKLIVAGASAYARTIDFKAFKEICDEVGALFMVDMAHIAGLVAAGEHPSPVPYADFVTSTTHKTLRGPRGGLILCKEKYAKQLDKTIFPGIQGGPLIHTIAAKAVCFKEALDPSYKDYIKNVINNCNVLSNELINYGFKIVSGGTDNHLILVDLTNKEVTGKDAEILLDSIGITVNKNTVPNETKSPFITSGIRIGTPAVTTRGFNEEDMKEVASIINDAISEKDPNLDLLRSRVKSLCEKHPLYN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ASRV01000079
EMBL· GenBank· DDBJ
EOR26927.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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