Essential maintenance is planned to begin on Tue Jan 28 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ during this time.

R4Z5D7 · R4Z5D7_9ACTN

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site13Mg2+ (UniProtKB | ChEBI)
Site18Substrate discrimination
Binding site103Mg2+ (UniProtKB | ChEBI)
Active site104

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA-templated DNA replication
Biological Processerror-prone translesion synthesis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB
    • ORF names
      BN381_810008

Organism names

Accessions

  • Primary accession
    R4Z5D7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-185UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    404
  • Mass (Da)
    43,635
  • Last updated
    2013-07-24 v1
  • MD5 Checksum
    712442ADD7B20D8D88145C44FC41653B
MRSTIEAGILHADLDAFYASVEQRDRPELRGRPMAVGGGVILAASYEARRRGVRGPMNIRAARALCPELIVVPPRMDAYTQASRRVFEIFDDTTPLVEPISIDEAFLDVSGLGRLVGAPKLVAARLRARVLAEVGLAISVGVARTKFLAKVASGVCKPDGLLVVEPDGELEFLHPLPVGRLWGVGPKTEEKLGRSGITTVGQVAELDEVRLVAMLGAGAGRQMHALAHNRDPRRVMTGKRRSSIGSQRALGQRRHGFAELEAILLELVDHVSRRLRDGNRVGRTVMLRFRFGDFTRDTRSHSVPEATGSTAAFLNASHGLLVARRDEIERRGLTLLGFTIANVSPADAVQQSLEFDGRSAVDLDGAVDAVRNRYGSDSIGRATLLGRSNGIHVPLLPDPGASRP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CANL01000080
EMBL· GenBank· DDBJ
CCM65905.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help