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R4Z2V6 · R4Z2V6_9ACTN

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site20-22shikimate (UniProtKB | ChEBI)
Binding site67shikimate (UniProtKB | ChEBI)
Active site71Proton acceptor
Binding site92shikimate (UniProtKB | ChEBI)
Binding site107shikimate (UniProtKB | ChEBI)
Binding site224NADP+ (UniProtKB | ChEBI)
Binding site226shikimate (UniProtKB | ChEBI)
Binding site247NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      BN381_50132

Organism names

Accessions

  • Primary accession
    R4Z2V6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-94Shikimate dehydrogenase substrate binding N-terminal
Domain122-182Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    281
  • Mass (Da)
    28,759
  • Last updated
    2013-07-24 v1
  • MD5 Checksum
    CEAFBE34252203289199DDE137B148ED
MVISGSTRLAGVIGNPVRHSMSPAIHNAAYEATGLDWAYVALPVTEDRVEAALLGAVALGLEGVSVTMPHKTAAAQFCDELTPAAARLGVVNSIRNVDGTLVGNNTDGTGFLRALLADGWSANGRRVVVVGAGGTARALTAALVDAGAEQVLVAARREEAALEVATMAGAGARGIRLEDMSASQWGDADLVANTTPVGMVGSARPDASPAPVAWLSSQCRVIDAVYHPLTTPLLAASRQRGLSTLGGVELLVGVSAEVFTWWTGVEAPMQVMVDAARTVLG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CANL01000045
EMBL· GenBank· DDBJ
CCM64990.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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