R4Z2V6 · R4Z2V6_9ACTN
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids281 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 20-22 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 67 | shikimate (UniProtKB | ChEBI) | |||
Active site | 71 | Proton acceptor | |||
Binding site | 92 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 107 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 224 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 226 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 247 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Acidimicrobiia > Acidimicrobiales > Microthrixaceae > Candidatus Microthrix
Accessions
- Primary accessionR4Z2V6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 12-94 | Shikimate dehydrogenase substrate binding N-terminal | |||
Domain | 122-182 | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | |||
Sequence similarities
Belongs to the shikimate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length281
- Mass (Da)28,759
- Last updated2013-07-24 v1
- MD5 ChecksumCEAFBE34252203289199DDE137B148ED
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CANL01000045 EMBL· GenBank· DDBJ | CCM64990.1 EMBL· GenBank· DDBJ | Genomic DNA |