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R4YVL3 · R4YVL3_9ACTN

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site240pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site277-280pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site280substrate
Binding site317substrate
Binding site321substrate
Active site348Proton donor
Binding site349substrate
Binding site378pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site378substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      BN381_10011

Organism names

Accessions

  • Primary accession
    R4YVL3

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue64N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain42-284Orn/DAP/Arg decarboxylase 2 N-terminal
Domain285-376Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    43,709
  • Last updated
    2013-07-24 v1
  • MD5 Checksum
    6DBB9B04C4F9218BA715BEBF2D32B258
MPRQLLPDTAETDGDGSLLIGGCRVVDLAEEFGTPLLVYDEAHLRARCQEAIAAFDGKVAYASKAFLCRAMAKLAYEEGMSIDVATGGEYGIARAAGVPAASLVFHGNNKSGVELNMALRDGVGRVVVDSFDELDRIEALVADGAPAPRVLIRVNPGIEVHTLDEVATGVPDSKFGFPLAAGDAERALARAGGSGAMELVGTHIHIGSQVFSAANFADALATLGPTVRGWGLDEFVVGGGLGVPYVTGEEAPTITQWAAGIRRACDELGITAAVSAEPGRSIAAAAGITVYRVGTIKEIEGVRTYVAVDGGMSDNPRPVLYGSGYETFLPRSVAAERPRTITLVGKHCESGDKLVVDGAVPDDLMVGDVIATPVTGAYGQSMGSNYNKVLRPPVVFVADGDARLVVRRETLEDLLATDLG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CANL01000001
EMBL· GenBank· DDBJ
CCM61780.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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