R4YVL3 · R4YVL3_9ACTN
- ProteinDiaminopimelate decarboxylase
- GenelysA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids420 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Catalytic activity
- meso-2,6-diaminoheptanedioate + H+ = L-lysine + CO2
Cofactor
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 240 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 277-280 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 280 | substrate | |||
Binding site | 317 | substrate | |||
Binding site | 321 | substrate | |||
Active site | 348 | Proton donor | |||
Binding site | 349 | substrate | |||
Binding site | 378 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 378 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | diaminopimelate decarboxylase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate decarboxylase
- EC number
- Short namesDAP decarboxylase ; DAPDC
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Acidimicrobiia > Acidimicrobiales > Microthrixaceae > Candidatus Microthrix
Accessions
- Primary accessionR4YVL3
Proteomes
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 64 | N6-(pyridoxal phosphate)lysine | |||
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 42-284 | Orn/DAP/Arg decarboxylase 2 N-terminal | |||
Domain | 285-376 | Orn/DAP/Arg decarboxylase 2 C-terminal | |||
Sequence similarities
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length420
- Mass (Da)43,709
- Last updated2013-07-24 v1
- MD5 Checksum6DBB9B04C4F9218BA715BEBF2D32B258
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CANL01000001 EMBL· GenBank· DDBJ | CCM61780.1 EMBL· GenBank· DDBJ | Genomic DNA |