R4VDZ1 · R4VDZ1_BBWV2

Function

function

Plays a role in RNA replication. It is covalently linked to the 5'terminus of both viral single-stranded RNA1 and RNA2 molecules.
Replicates the viral genome.
The protease cofactor and the putative helicase seem to target the replication complexes to ER membranes. Their physical association causes the membrane rearrangement of host ER that may result in formation of the small membranous vesicles that are the site of viral RNA synthesis.
Thiol protease that cleaves the RNA1 and RNA2 polyproteins.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell endoplasmic reticulum
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    RNA1 polyprotein
  • Alternative names
    • Genome polyprotein B

Organism names

  • Taxonomic identifier
  • Strain
    • PAP2
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Secoviridae > Comovirinae > Fabavirus > Fabavirus betaviciae

Accessions

  • Primary accession
    R4VDZ1

Subcellular Location

Endoplasmic reticulum
Host endoplasmic reticulum
Host membrane
; Single-pass membrane protein
Membrane
; Single-pass membrane protein

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain485-653SF3 helicase
Domain962-1164Peptidase C3
Domain1444-1571RdRp catalytic

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,869
  • Mass (Da)
    210,017
  • Last updated
    2013-07-24 v1
  • Checksum
    194F842BB98CF65D
MDFSMMQMTVSFLKTSMGLQSIKDIVEKACVAEKDKTLLHIHLCFFHANEMARDFNEGMDMGQIQSSAAIKYRAAVLKRHVVMNVETGRYDRARMMQYNNETCVNWFSCGIVEEKAKQILDEEEAQEGNIVDNFLKSCAISEEVGQTSGEGAEHYAFGQGLYEYATRISDAIVAVISGSIKKSIDDFLDKVYAVMAQVFAAWMPRIRAAFQWFENIKEVIKRWANSMHEKINFILVGMEDCLYMGAGLVAATCIVTLLEKFMIAIGILTKPCGAATLFLTTAMAAISATYVCGKALEKSAMLTNLLLFVTTNCRVVLDTLFNHELGRQEQETSQNDEKAPTGFGQFGVSTMLQDVANLVSTWSTSSVTEIGKTFGAISQIKNGILALRDMVYFVFEKLSELAHRVLGFESQVLADLSVLLGENVADWLCECDCMVAYMLEFNSRNREIFDRLSQLIEKGRMIRTGVLRSSHRGSSQVMSLVTKALEKLIELHNSVVMAGSNTTRKSPFMVFFTGASGTGKTSVVQRVAINWLQEEQLGTSEIYARNGQDPFWSGYKRHAVVTYDDFGAVPGTTSNEAEIINVISRNPYATVMAGLAEKGMYFDSRLVLASSNFLAANPESGVHDSEAYERRRHAVVRVSLKPGVPYNANDPCANQTYTLLESKTPFNEIQVFETYAELWSFLYTRFKEHEEQEELYLKSLPILDSDKKEALEGLVGLTVIATSFAPKAVMQFGAEKFPGYHFLISDGEYCYFWHGDGSVEFVSVEQMKLGKQDIIQLKQQGLSTAMMYKDLAKAFPTLNSLAVLYAKNIVVKRWIGANLEPTKSCEDVYMREQIGNLPKWQRAYLHVLSKYLTVQSPRGWFMECLEEAKRNLRATYLWEYKQWPLPLKLALGSLIAIMAGGAIWYSLQSLWCVSGDASFIAGAATVFSVSSFAGQSDVPNRDNSERSFRNRKIRARTWQGQSSCFGDSALWIAETCMATLTFSNVRTQVCLAPGRGFFGVNHCLAAIPAGVMVKLDSSIGVTYFVWEKEKLTQFEGNEIALYMTSTMPKTVDSLLSRIHFDAETLPKTFNAVFFSYKYDPVIQQMVPELGSVTCKIHNKAFTLAHGEYRREIPQSLTYEASTVAGDCGSLILAEIEGKFKLVGMHVAFNGKEGSASFMPYHASLDQKVGQGDFVLKYQEWAEPKILGPGCRAMGLIDPEHALAASGKTTFVETPEEWHLNYPCDKLPSILARGDPRLAGTVHADYDPFAAGMSKYAKEAGPFDASSLKQVCLGITEVWEDASADFPMDEVDLDTAINGLENVEFFDALVLGTSEGFPYRLDRGPGEKGKSRYVSGESGNFKITDEGVLSDINWFEETSRTQVPDLYCIECVKDERLPVRKVLHEPKSRLFTVLPMSYNIAIRKKFLNFVRFFMKRRDVLPAQVGVNPYSREWTRIANKLLSKGNNILCCDYSRFDGFLPKCIMNEIGDMIARVMRANDESKTQIKNLMLACTSRYAMCNRILYRVENGIPSGFPLTVIVNSILNEILVKYAYWHCFVDNPTVQSNFDAHVSMVVYGDDNLISVSDAISSKFDGNFLVKFMEGLGVKVTDGIDKMKIGIEFRRLENCDFLKRSFKLNPDGTWRSPMSKESLWPQLHYVKAKKLEMAEAYINNCNNILRELWLHDVTEAKEFRNRVLRNLKWIGHEQLLNMQQLAVFHSEQMNGISDFLSTCVAVDSISLMDPLVPGLLPVKTCEVIPRIFVAAEKHFEGNFEDFFTVSITTSRKFKEDKGFVLLFPYGAGRGGLPTTQFMKENVVRKGCSIQKKFRQAYERGEKILFISQSSVVPAYVFAVMLLHSIGAISRLTSNKALTQAMQTCKKLEYLPKEYEDFF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC625501
EMBL· GenBank· DDBJ
AGM38168.1
EMBL· GenBank· DDBJ
Genomic RNA

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