R4SCC4 · R4SCC4_HUMAN

  • Protein
    hypoxia-inducible factor-proline dioxygenase
  • Gene
    EGLN1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    2/5

Function

Catalytic activity

Cofactor

L-ascorbate (UniProtKB | Rhea| CHEBI:38290 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionferrous iron binding
Molecular FunctionL-ascorbic acid binding
Molecular Functionpeptidyl-proline 4-dioxygenase activity
Biological Processcellular response to hypoxia

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    hypoxia-inducible factor-proline dioxygenase
  • EC number

Gene names

    • Name
      EGLN1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    R4SCC4

Subcellular Location

PTM/Processing

Proteomic databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain21-58MYND-type
Region65-184Disordered
Compositional bias92-108Basic and acidic residues
Domain291-392Fe2OG dioxygenase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    426
  • Mass (Da)
    46,019
  • Last updated
    2013-07-24 v1
  • Checksum
    5241F67B43483B05
MANESGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPSRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias92-108Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC554019
EMBL· GenBank· DDBJ
AGL94896.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554020
EMBL· GenBank· DDBJ
AGL94897.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554021
EMBL· GenBank· DDBJ
AGL94898.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554022
EMBL· GenBank· DDBJ
AGL94899.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554024
EMBL· GenBank· DDBJ
AGL94901.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554025
EMBL· GenBank· DDBJ
AGL94902.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554026
EMBL· GenBank· DDBJ
AGL94903.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554027
EMBL· GenBank· DDBJ
AGL94904.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554028
EMBL· GenBank· DDBJ
AGL94905.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554032
EMBL· GenBank· DDBJ
AGL94909.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554036
EMBL· GenBank· DDBJ
AGL94913.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554047
EMBL· GenBank· DDBJ
AGL94924.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554049
EMBL· GenBank· DDBJ
AGL94926.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554050
EMBL· GenBank· DDBJ
AGL94927.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554054
EMBL· GenBank· DDBJ
AGL94931.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554055
EMBL· GenBank· DDBJ
AGL94932.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554056
EMBL· GenBank· DDBJ
AGL94933.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554057
EMBL· GenBank· DDBJ
AGL94934.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554060
EMBL· GenBank· DDBJ
AGL94937.1
EMBL· GenBank· DDBJ
Genomic DNA
KC554062
EMBL· GenBank· DDBJ
AGL94939.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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