R4SCC4 · R4SCC4_HUMAN
- Proteinhypoxia-inducible factor-proline dioxygenase
- GeneEGLN1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids426 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ferrous iron binding | |
Molecular Function | L-ascorbic acid binding | |
Molecular Function | peptidyl-proline 4-dioxygenase activity | |
Biological Process | cellular response to hypoxia |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namehypoxia-inducible factor-proline dioxygenase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionR4SCC4
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-58 | MYND-type | ||||
Sequence: CELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVC | ||||||
Region | 65-184 | Disordered | ||||
Sequence: LGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPSRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQ | ||||||
Compositional bias | 92-108 | Basic and acidic residues | ||||
Sequence: EPRKAAARRDNASGDAA | ||||||
Domain | 291-392 | Fe2OG dioxygenase | ||||
Sequence: KINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFD |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length426
- Mass (Da)46,019
- Last updated2013-07-24 v1
- Checksum5241F67B43483B05
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 92-108 | Basic and acidic residues | ||||
Sequence: EPRKAAARRDNASGDAA |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KC554019 EMBL· GenBank· DDBJ | AGL94896.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554020 EMBL· GenBank· DDBJ | AGL94897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554021 EMBL· GenBank· DDBJ | AGL94898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554022 EMBL· GenBank· DDBJ | AGL94899.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554024 EMBL· GenBank· DDBJ | AGL94901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554025 EMBL· GenBank· DDBJ | AGL94902.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554026 EMBL· GenBank· DDBJ | AGL94903.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554027 EMBL· GenBank· DDBJ | AGL94904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554028 EMBL· GenBank· DDBJ | AGL94905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554032 EMBL· GenBank· DDBJ | AGL94909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554036 EMBL· GenBank· DDBJ | AGL94913.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554047 EMBL· GenBank· DDBJ | AGL94924.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554049 EMBL· GenBank· DDBJ | AGL94926.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554050 EMBL· GenBank· DDBJ | AGL94927.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554054 EMBL· GenBank· DDBJ | AGL94931.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554055 EMBL· GenBank· DDBJ | AGL94932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554056 EMBL· GenBank· DDBJ | AGL94933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554057 EMBL· GenBank· DDBJ | AGL94934.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554060 EMBL· GenBank· DDBJ | AGL94937.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC554062 EMBL· GenBank· DDBJ | AGL94939.1 EMBL· GenBank· DDBJ | Genomic DNA |