Inhibiting PHD2 in human periodontal ligament cells via lentiviral vector-mediated RNA interference facilitates cell osteogenic differentiation and periodontal repair.
The authors did not detect prolyl-hydroxylase activity on any reported non-HIF protein or peptide using conditions supporting robust HIF-alpha hydroxylation.
findings reveal a differential dependency of clear cell ovarian cancers on EGLN1 thus identifying EGLN1 as a potential therapeutic target in clear cell ovarian cancer patients
Both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) had elevated PHD2 (EGLN1) expression compared to normal tissues. High PHD2 expression LUAD but not LUSC patients had shorter overall (OS) and recurrence-free survival (RFS) compared to the low expression group. High methylation level of these two CpG sites (cg07040244 and cg21875980) in PHD2 was associated with better OS in LUAD patients.
During the transition of nevi to melanoma the expression of PHD2 protein is significantly decreased and lower expression of PHD2 in melanoma is associated with worse clinical outcome. Knockdown of PHD2 leads to elevated Akt phosphorylation in melanocytes.
The overall results indicate how the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain achieves selectivity for HIFalpha oxygen-dependent degradation domains.
GPT2 reduced alpha-ketoglutarate level in cells leading to the inhibition of proline hydroxylase 2 (PHD2) activity involved in the regulation of HIF1alpha stability. Accumulation of HIF1alpha resulting from GPT2-alpha-ketoglutarate-PHD2 axis constitutively activates sonic hedgehog (Shh) signaling pathway.
Phd2 is the dominant HIF-hydroxylase in neutrophils under normoxic conditions; intrinsic regulation of glycolysis and glycogen stores is linked to the resolution of neutrophil-mediated inflammatory responses
the expression of prolyl hydroxylase domain 2 (PHD2) is selectively increased in CKD-AT-MSCs and its inhibition can restore the expression of HIF-1alpha and the wound healing function of CKD-AT-MSCs. These results indicate that more studies about the functions of MSCs from CKD patients are required before they can be applied in the clinical setting
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