Inhibiting PHD2 in human periodontal ligament cells via lentiviral vector-mediated RNA interference facilitates cell osteogenic differentiation and periodontal repair.
The authors did not detect prolyl-hydroxylase activity on any reported non-HIF protein or peptide using conditions supporting robust HIF-alpha hydroxylation.
PHD2 is the key regulatory enzyme of BRD4 proline hydroxylation and the modification significantly affects BRD4 interactions with key transcription factors as well as BRD4-mediated transcriptional activation.
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