R4R1L5 · R4R1L5_BEMTA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      CO1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    R4R1L5

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-47Helical
Transmembrane59-82Helical
Transmembrane94-116Helical
Transmembrane136-159Helical
Transmembrane171-193Helical
Transmembrane213-236Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-267Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    267
  • Mass (Da)
    29,633
  • Last updated
    2013-07-24 v1
  • Checksum
    5B0B9BAFDA9AE08D
VLILPGFGIVSHLISSEAGKLEVFGSLGMIYAMVTIGILGFIVWGHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLGGMKSNSFSPLGLWFTGFLFLFTMGGLTGIILGNSSVDVCLHDTYFVVAHFHYVLSMGIIFAIVGGVIYWFPLILGLTLNSHSLVSQFYIMFLGVNLTFFPQHFLGLSGMPRRYSDYPDCYLMWNKISSAGSILSIISVIYFLFIVLESLLLLRLVGFKLGMISYLEWKINKPSLQHSFKELGL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue267

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC876574
EMBL· GenBank· DDBJ
AGL76548.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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