R4MY31 · R4MY31_9CALI
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2334 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.
Displays NTPase activity, but no helicase activity. Induces the formation of convoluted membranes derived from the host ER. These remodeled membranes probably form the viral factories that contain the replication complex. Together with NS2 and NS4, initiates the formation of the replication complex.
Probable key protein responsible for the formation of membrane alterations by the virus. Induces the formation of convoluted membranes derived from the host ER. These remodeled membranes probably form the viral factories that contain the replication complex. Together with NS2 and NTPase, initiates the formation of the replication complex.
Replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs.
Together with NTPase and NS4, initiates the formation of the replication complex. Induces the proliferation of the host smooth ER membranes forming long tubular structures. These remodeled membranes probably form the viral factories that contain the replication complex.
Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation. Interacts with host translation initiation complex to allow the translation of viral proteins.
Catalytic activity
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasm | |
Cellular Component | membrane | |
Cellular Component | viral capsid | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
- Alternative names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Lagovirus
Accessions
- Primary accessionR4MY31
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 368-388 | Helical | |||
Transmembrane | 400-421 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length2,334
- Mass (Da)255,602
- Last updated2013-07-24 v1
- MD5 ChecksumA5A4743387B15BA21577D3EB8CCCB102
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KC832838 EMBL· GenBank· DDBJ | AGL33699.1 EMBL· GenBank· DDBJ | Genomic RNA |