R4MY31 · R4MY31_9CALI

Function

function

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.
Displays NTPase activity, but no helicase activity. Induces the formation of convoluted membranes derived from the host ER. These remodeled membranes probably form the viral factories that contain the replication complex. Together with NS2 and NS4, initiates the formation of the replication complex.
Probable key protein responsible for the formation of membrane alterations by the virus. Induces the formation of convoluted membranes derived from the host ER. These remodeled membranes probably form the viral factories that contain the replication complex. Together with NS2 and NTPase, initiates the formation of the replication complex.
Replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs.
Together with NTPase and NS4, initiates the formation of the replication complex. Induces the proliferation of the host smooth ER membranes forming long tubular structures. These remodeled membranes probably form the viral factories that contain the replication complex.
Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation. Interacts with host translation initiation complex to allow the translation of viral proteins.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componentmembrane
Cellular Componentviral capsid
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein
  • Alternative names
    • p254

Organism names

  • Taxonomic identifier
  • Strain
    • O4022-10_1982
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Lagovirus

Accessions

  • Primary accession
    R4MY31

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane368-388Helical
Transmembrane400-421Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain487-647SF3 helicase
Domain1102-1237Peptidase C24
Domain1488-1612RdRp catalytic
Region1760-1784Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,334
  • Mass (Da)
    255,602
  • Last updated
    2013-07-24 v1
  • MD5 Checksum
    A5A4743387B15BA21577D3EB8CCCB102
MAVASRPCGVATSVLPAKKPLSFFTDLVGKTPPRCIRAPHTLAWPVFVDLDNEDESPEICRKCGKYANGFGVFDLTDLGDVCLCSIQPQRHVGGPCCLCNKQYIRACGRYCARVLKHYKAFNKVIPCLYSRQVKPVFEGEVEDLFVELGAPTTMNFTEADLASQGASIMDRFVDLVEPCLSAEDSTFLDNICSDASIRKRLEDEYGVDMIAAARARKDFAKTLKLALKDREKKPDKWYSKLGCITTKGRQWAKKVVHGAKKLSDPLKTLAAILLVALHNCVAVDTTTMLSHFKPVNLLAILLDWTNDLPGFLTTLIRLMELYGVVQSTVNLIVDAIKSFWDRVMCATERCCDLLKRLFDKFEDSVPTGPTAGCLIFMSFVFSIIVGYLPNNSVISTFMKGAGKLTTFAGVIGAIRTLWITINQHMVAKDITSIQEKVMAVVKMANEAATLSQLEIVSVLCSELESTLTNRCTLPSYNQHMGVLNAAQKVVTDIHTLVIGKINMTKQRPQPVAIVFKGAPGIGKTYLVHRLAKDLGCPHPSNINFGLDHFDSYTGEDVAIADEFNTSGDERWVELFIQMVNTNPCPLNCDKVENKNKVFSSKYLLCTTNSSMVLNATHPRATAFYRRVIIVDVRNKAVEGWQSTRHGSKPGKFCYNKDMSHLTFQVYPHNMPAPGFVFVGEKLVKSQVVPRELKYNELLDMIKNEHPDANFEGATXHEFVYPDVQYEQALLMWKQYFLMYGCTARLAKVFVDDIPYNQIHIAKRSDPRSPGAVHHDCELKYIWRMVPHFALGCVNMTNQLGTDLTQSQLDRITCGVEGITVTTVDNILPFHSQNTLINPSFLKLIWALRRHLRGLRGITQVATFIWKVMCNPVCAYDTLIRTLTGAATFSEDPVTTTIICPNCTIQIHTCGGLLVRYSGDPAPVASDNVDRGNQGIDCLTNPNLIAGFSWRQIADLFSTVMTSLCNNHLVNLATMAALGAVATKALQGVKGKTKRGRGARINLGNDEYDEWQQLRREFNNAHDMTAEEFLELRNRAAMGSDDADAIKFRSWWTNRQLRQDEAHVTVIGKGGVRNEVIRTRVRNAPKGPKTLDDGGFYDNDYEGMPGYLRFNGSGWMIHIGNGMYLSNTHTARSSCSEIVTCSPTTDLCLVKAEPIRSVAQIAEGTPVRDWKKASITTYGLKKTFSDSTKIDVLAYDGPTQTTHGDCGLPLFDEAGKVVAIHTGKLLGFSKMCTLIDCTITKGVYENTDLFCGDPIDYRGLVAFRVAGVEPRPPVSGTRYAKVPGVPEEYHTGYRPANLGRGDPDSHCTLMNIAVKNLQVYQQEPKLTKVDTFIERAAADVLGFLRFLTKGERQMNLNFSAAFNVLDLSTSCGPFVPGKKIDHVKDGKLDEVLSKHLYKCWSVANSGKALHHVYACGLKDELRPLAKVKEGKKRLLWGCDVGVALCAAAVFHNLCFKLKTVARFGPIAVGIDMTSRDVDVMITQLTSKAGDFLCLDYSKWDSTMSPCVVRLAIDLLADCCEQTELTKSVVLTLKSLPMTVLDAMIVPTKRGLPSGMPFTSVINSICHWLLWSAAVYKACDEIGLFCSNLYEDAPFFVYGDDGVYAMTPMMVSLLPAILDNLRDYGLSPTAADKTEFIDVCPLKDISFLKRKFVMSELGWLSQLDRSSILRQLEWTKTAKRHMCIEECSELDKDERGVQLEELQIHAAAHGQEFFELVTKELRRQQAFTRFCVFDYQTARKTLGDRKRIVSVVPDDSFVNVMEGKPRADAPGTATTASVPGTTTDGMDPGVVASTDVVTADNVAASVATAGIGGPPQQASPQESWRMNFFYNDVFTWSVTDAPGSILYTVQHSPQNNPFTQVLSQMYAGWAGGMQFRFIVAGSGIFGGRLVCAIIPPGIQIQPGLEVRQFPHVVIDARSLEPVTITMPDLRPEMYHPTGDPGLVPTLVVSVYNNLINPFGGTTSAIQVTVETRPSEDFEFVLIRAPSSRTVDSVNPSWLLTTPVLTGAGSDNRWGAPIVGLQPVPGGFSTSNRHWNMNGATYGWSSPRFDDIDHPSGNVSYPTGSATNTIETWYASVGTATTNPISNVAPDGFPDMGAIPFSGTTIPTGAWVGFGQVWNAANGTPYVGTVQAYELGFATGAPSSIRPVTTTAGAQLVAKSIYGVAIAQNQSSAGIIFLSKGMVSTPGVAATTYTPQPSAIVTTPGTPVAAPIGKNTPIMFSAVVRRTGDVNAGAGSDNGTQYGVGSQPLSVTLGLSLTNYSSALQPGQFFVWQLNFASGFMEVGMNTDGYFYAGTGASSAMIDLTDLIDVRPVGVRPNTSTLVFNLAGVATTGYSYV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC832838
EMBL· GenBank· DDBJ
AGL33699.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help