R4K7G3 · R4K7G3_CLOPA

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

111421002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site119ATP (UniProtKB | ChEBI)
Binding site203ATP (UniProtKB | ChEBI)
Binding site238ATP (UniProtKB | ChEBI)
Active site295
Binding site537Mn2+ (UniProtKB | ChEBI)
Binding site609substrate
Binding site706Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site735Mn2+ (UniProtKB | ChEBI)
Binding site737Mn2+ (UniProtKB | ChEBI)
Binding site870substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • ORF names
      Clopa_4405

Organism names

Accessions

  • Primary accession
    R4K7G3

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue706N6-carboxylysine
Modified residue1108N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-456Biotin carboxylation
Domain123-320ATP-grasp
Domain528-796Pyruvate carboxyltransferase
Domain1067-1142Lipoyl-binding

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,142
  • Mass (Da)
    127,343
  • Last updated
    2013-07-24 v1
  • Checksum
    C16AD5572E784BD0
MKEFKRVLVANRGEIAIRIFRACKELGIRTVAIYSNEDKYSLFRTKADEAYLIGENKSPVEAYLNIEEIISLALKKGVDAIHPGYGFLSENAEFAKKCAEAGIEFIGPTSEMMDKLGDKIKSKIAAKAVGVSTIPGYERDIKTVEEAKKLAKECGYPIMLKAAAGGGGRGMRIVRNEEELPDAFMSAKSEAKKAFGIDVMFMEKYLEKPKHIEVQVLGDKYGNIVHLHERDCSIQRRHQKVIEFTPAFSLSDEKRNKICEDALKIARSVNYRSAGTLEFLVDANGNHYFIEMNPRVQVEHTITEMITGIDIVQSQILIAEGYELGSEEIGIYSQDDIKINGYSIQCRITTEDPFHNFAPDTGKIEVYRTSSGFGIRLDGGNGFSGAVISPYYDSLLVKNISWSRTFKDCVRKTIRAIKETNITGVKTNIGFLINVLNHPTFLKGECDTGFIDENPELINILPHEDEEGRLLKFIGEKVVNETKGIKKEYDVPVVPKVEIQDTLIGTKQLLDTKGTEGLVSWIKDQSKLLLTDTTMRDANQSLMATRVRTRDMIKIAEATSAYGKDLFSLEMWGGATFDVAYRFLGESPWERLAQLRKKIPNVLFQMLIRGANAVGYKNYPDNVIREFIRESANNGIDVFRIFDSLNWLKGMEVSIDEVLKSGKVAEACICYTGDILNDKKTKYNLDYYIKLAKEIEKTGAHILGIKDMSALLKPHAAYKLVGALKQEIGMPIHLHTHDTTGNGVATVLMAAEAGVDIVDTAFNSMSGLTSQPALNSVAAALKNTRRDTGIDLRGIQRVSDYWAAVRPVYYKFESELKSGSAEIYEYEIPGGQYSNLKPQVESFGLGHKFNEIKAMYKKVNDMLGDIVKVTPSSKMVGDFAIFMVQNDITPENIYDKAVNMAFPDSVVAYFKGMMGQPMEGFPKKLQDLVLKGEEPITCRPGELLPEEDFNKIEEYLKDKYDIAPNKKDALSYALYPDVFEDYLNYIKEFGDLSRLGSDVYFHGLSEGETCEAEVANGKTYMIKLSGMGKVDQEGNKTLYFEVDGNRREIKIKDRDSKNAQETFSTKMADSSNPLEVGAPIPGTILKVLVSEGEKVSENQPLMIVEAMKMETRVSASASGTVELINASEGQQVKAGELLISLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003261
EMBL· GenBank· DDBJ
AGK99117.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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