R4J944 · R4J944_9BILA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Gnathifera > Rotifera > Eurotatoria > Monogononta > Pseudotrocha > Ploima > Brachionidae > Brachionus

Accessions

  • Primary accession
    R4J944

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-42Helical
Transmembrane54-73Helical
Transmembrane103-127Helical
Transmembrane147-171Helical
Transmembrane183-212Helical
Transmembrane245-265Helical
Transmembrane272-293Helical
Transmembrane305-330Helical
Transmembrane342-362Helical
Transmembrane382-403Helical
Transmembrane415-436Helical
Transmembrane456-476Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-516Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    516
  • Mass (Da)
    57,740
  • Last updated
    2013-07-24 v1
  • Checksum
    93F3AEDC15FA78EF
MLKLMRWLTSTNHKDIGTLYFIFGIWAGLIGLSMSFLIRLELGVVGSYIGDEHLYNVLVTAHAFVMIFFMVMPVSMGGFGNWLIPLMLGVADMAFPRMNNLSFWLLVPAFILLLLSSAIDAGVGTGWTVYPPLSDSTYHAGVSVDLAIFSLHLSGISSILGSINFLTTIICSRTTKSVSLDRLPLMLWAIAVTAVLLITSLPVLAGAITMLLTDRNFNTSFFDPAGGGNPVLYQHLFWFFGHPEVYILILPGFGMVSHIILAYSFKKEIFGYYGMVYAMVSIGLLGFIVWAHHMFTVGLDVDTRAYFTAATMTIAVPTGVKIFSWLASLYGSKNISTSVPLLWVKGFIFLFTLGGLTGILLSNSSIDVLLHDTYYVVAHFHYVLSMGIVFAIFGGFFYWFPVFTGLGLNDYLGKVHFYLTFIGVNLTFFPQHFLGLSGMPRRYADYPDCYYVWNKVSSLGSFMTIFSVMLFIIILWEAFVSRRTVMFTYHNPVHLEWSPRPPIAFHSHVEAVKVFY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC603850
EMBL· GenBank· DDBJ
AGI78543.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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