R4GNG2 · R4GNG2_HUMAN

  • Protein
    Autocrine motility factor receptor
  • Gene
    AMFR
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Variants

129920406080100120140160180200220240260280
GAVLISTCMDNEQRKHFYWPd*GAVLISTCMDNEQRKHFYWPd*
Variant
ID(s)
Position(s)ChangeDescriptionClinical
significance
Provenance
rs19611924831Y>*Ensembl
rs14672366544T>PgnomAD
rs19611920855S>CTOPMed
gnomAD
rs19611920855S>FTOPMed
gnomAD
rs19611920855S>YTOPMed
gnomAD
rs7739042616G>RExAC
gnomAD
rs7681266009W>*ExAC
TOPMed
gnomAD
rs7681266009W>CExAC
TOPMed
gnomAD
COSV51922530
rs1961191710
9W>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
TOPMed
rs196119119210P>STOPMed
rs196119119210P>TTOPMed
rs144085501211A>VgnomAD
rs214384398912W>LEnsembl
rs128002539417S>ITOPMed
rs128002539417S>TTOPMed
rs196119060618C>FEnsembl
rs74900865319V>IExAC
TOPMed
gnomAD
rs77956153021C>RExAC
gnomAD
rs122627979022F>LTOPMed
gnomAD
rs144186428823M>LTOPMed
gnomAD
rs53510398423M>T1000Genomes
ExAC
TOPMed
gnomAD
rs144186428823M>VTOPMed
gnomAD
rs74733912524R>KExAC
TOPMed
gnomAD
rs196118925425C>WEnsembl
rs11174428426N>STOPMed
rs128364091027V>ITOPMed
gnomAD
rs20137325930V>IVariant of uncertain significance (Ensembl)1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs76547720431G>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
ExAC
TOPMed
dbSNP
gnomAD
rs75509379032T>RExAC
gnomAD
COSV51920340
rs1961187168
33R>I
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
Ensembl
rs196118684734T>ATOPMed
rs214384367735I>TEnsembl
rs139747261635I>VgnomAD
rs144239384936Y>FTOPMed
COSV51922857
rs766511582
37V>M
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
TOPMed
dbSNP
gnomAD
rs129797725238W>*gnomAD
rs142064628140E>KgnomAD
COSV99315692
rs1382723707
42W>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
dbSNP
gnomAD
rs95034791343R>KgnomAD
rs76090678943R>SExAC
gnomAD
rs77290788345G>RExAC
gnomAD
rs76158574946L>FExAC
TOPMed
gnomAD
rs36943366746L>SVariant of uncertain significance (Ensembl)1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs36943366746L>WVariant of uncertain significance (Ensembl)1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs196115120747Q>*TOPMed
rs124622890747Q>RTOPMed
gnomAD
rs214384026648L>FEnsembl
rs75129979551Q>HExAC
TOPMed
gnomAD
rs76402414253S>RExAC
TOPMed
gnomAD
rs121893493255L>PgnomAD
COSV51921317
rs1341972825
57T>A
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
TOPMed
dbSNP
gnomAD
rs127345005457T>IgnomAD
rs133220316458M>IgnomAD
rs77491193058M>LExAC
TOPMed
gnomAD
rs77491193058M>VExAC
TOPMed
gnomAD
rs132617267559T>MTOPMed
gnomAD
rs140499212161V>AgnomAD
rs75917679564V>AExAC
gnomAD
rs117146637166T>AgnomAD
rs15130119066T>N1000Genomes
ExAC
gnomAD
rs15130119066T>S1000Genomes
ExAC
gnomAD
rs20025929568C>*1000Genomes
ExAC
gnomAD
rs20212161168C>F1000Genomes
ExAC
gnomAD
rs115730014469R>SgnomAD
rs76930583371R>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
ExAC
dbSNP
gnomAD
rs75803081971R>HExAC
TOPMed
gnomAD
COSV51920040
rs756216374
72G>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
dbSNP
gnomAD
rs15079835973N>DVariant of uncertain significance (Ensembl)ESP
ExAC
TOPMed
gnomAD
rs15079835973N>HVariant of uncertain significance (Ensembl)ESP
ExAC
TOPMed
gnomAD
rs196114792673N>ITOPMed
rs130892542273N>KgnomAD
rs196114771874C>FEnsembl
rs214383992376V>AEnsembl
rs196114735777D>ATOPMed
gnomAD
rs121825720878I>MTOPMed
gnomAD
rs101654652878I>TEnsembl
rs196114696479F>STOPMed
rs53322743582R>STOPMed
COSV51922153
rs1393940024
84R>Q
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
dbSNP
gnomAD
TCGA novel
rs1960639093
84R>W
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
gnomAD
rs127677250086A>VTOPMed
gnomAD
COSV51922948
rs1313900274
90P>L
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
TOPMed
dbSNP
gnomAD
rs159691076291S>REnsembl
rs75698366893S>LExAC
TOPMed
gnomAD
rs100155873196V>MEnsembl
rs142346724699T>SgnomAD
rs1960637347100T>ATOPMed
rs200380370101N>SESP
ExAC
TOPMed
gnomAD
rs754134863102I>MExAC
gnomAD
rs1211360303104G>DTOPMed
gnomAD
rs761117811105I>VVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
rs1215877770106T>AgnomAD
rs139530029106T>MESP
ExAC
TOPMed
gnomAD
rs1241932870107Q>HgnomAD
rs1339526362108A>SgnomAD
rs1293577986109S>GgnomAD
rs1596910645110N>DEnsembl
rs1960635618110N>KTOPMed
gnomAD
rs1960635774110N>SEnsembl
rs762158280114N>SExAC
TOPMed
gnomAD
COSV51922333
rs370219059
116M>V
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ESP
TOPMed
dbSNP
gnomAD
rs761815566117A>SExAC
gnomAD
rs762380239118H>LTOPMed
gnomAD
rs762380239118H>RTOPMed
gnomAD
rs774427539118H>YExAC
TOPMed
gnomAD
rs764446288119Q>RExAC
TOPMed
gnomAD
rs1474400860121Q>ETOPMed
rs1214944180123M>IgnomAD
rs1214774082130H>RgnomAD
rs1341959964131L>VgnomAD
rs2038162038132V>IEnsembl
rs1233174971133L>RTOPMed
gnomAD
rs1476987616137Q>HgnomAD
rs746531745139T>SExAC
gnomAD
rs1399609784140R>CTOPMed
gnomAD
rs777288075140R>H
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
ExAC
dbSNP
gnomAD
rs777288075140R>LExAC
gnomAD
rs2038161526141S>LTOPMed
rs1287694420142V>AEnsembl
rs2038161356143E>KEnsembl
rs2038161241144I>VTOPMed
rs2038161194145T>KEnsembl
rs747763305146T>AExAC
gnomAD
rs780460697150L>IExAC
gnomAD
rs750744117153R>P1000Genomes
ExAC
TOPMed
gnomAD
COSV51924688
rs750744117
153R>Q
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs1194982463153R>WTOPMed
gnomAD
rs2038160702154I>STOPMed
rs2038160750154I>VEnsembl
rs2038160591156V>AEnsembl
rs1439133146158F>SgnomAD
rs1276953002159P>SgnomAD
rs1238567489161Q>HgnomAD
rs751616370161Q>LExAC
gnomAD
rs751616370161Q>RExAC
gnomAD
rs768734279162R>LExAC
TOPMed
gnomAD
rs768734279162R>QExAC
TOPMed
gnomAD
rs202074356162R>WVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
COSV51924300
rs1596894284
166I>V
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
Ensembl
rs773117196174V>AExAC
gnomAD
rs771935701176R>KExAC
gnomAD
rs1236765937177P>LTOPMed
gnomAD
COSV51920505
rs1207778284
177P>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
TOPMed
dbSNP
gnomAD
rs761320091178S>GExAC
TOPMed
gnomAD
rs2038134783178S>NTOPMed
rs1440237184178S>RTOPMed
rs2038134673179S>NTOPMed
rs773814282180D>GExAC
gnomAD
rs1337139753180D>NTOPMed
gnomAD
rs1337139753180D>YTOPMed
gnomAD
rs1567505455183E>*Ensembl
rs2038134352183E>GgnomAD
rs1567505455183E>KEnsembl
rs1360983546184G>VgnomAD
rs1455589662186T>AgnomAD
rs1236612124187S>CTOPMed
gnomAD
rs546529393190T>A1000Genomes
rs760529496190T>IExAC
TOPMed
gnomAD
rs760529496190T>NExAC
TOPMed
gnomAD
rs761694034191E>KExAC
TOPMed
gnomAD
rs761694034191E>QExAC
TOPMed
gnomAD
rs201184108192R>CVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
rs144358339192R>HESP
ExAC
TOPMed
gnomAD
rs775195940196D>GExAC
TOPMed
gnomAD
rs2143729785197L>VEnsembl
rs2038073537199P>SgnomAD
rs769274825200R>CExAC
TOPMed
gnomAD
rs370746686200R>HESP
ExAC
TOPMed
gnomAD
rs1195500870202E>DTOPMed
gnomAD
rs2038073122202E>QgnomAD
rs373344016204T>MESP
ExAC
gnomAD
rs748633685206D>GExAC
TOPMed
gnomAD
rs748633685206D>VExAC
TOPMed
gnomAD
rs778922910207F>LExAC
TOPMed
gnomAD
rs755068171208G>SLikely benign (Ensembl)ExAC
gnomAD
rs149614022209E>KESP
ExAC
TOPMed
gnomAD
rs1596890700210V>GEnsembl
rs138247111212V>LESP
ExAC
TOPMed
gnomAD
rs138247111212V>MESP
ExAC
TOPMed
gnomAD
rs2038071744214P>LEnsembl
rs750243649214P>TExAC
gnomAD
rs761172267217V>GEnsembl
rs767281747218E>KExAC
gnomAD
rs751494058220F>LExAC
TOPMed
gnomAD
rs763570636221E>*ExAC
TOPMed
gnomAD
rs762540065221E>DExAC
gnomAD
rs763570636221E>KExAC
TOPMed
gnomAD
rs1223587728221E>VTOPMed
rs1378560642222A>PgnomAD
rs2038070923223R>CEnsembl
COSV51922655
rs764962608
223R>H
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
TOPMed
dbSNP
gnomAD
rs764962608223R>LExAC
TOPMed
gnomAD
rs1213114768225S>NTOPMed
gnomAD
COSV99315815
rs1419932705
226R>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
dbSNP
gnomAD
rs995498781226R>HTOPMed
rs1180317441228S>AgnomAD
rs2038070315228S>CTOPMed
rs1436681806229K>RgnomAD
rs898495076230S>FEnsembl
rs772556860232D>AExAC
gnomAD
rs2038069971233E>KTOPMed
rs1378595205234R>KgnomAD
rs1211581817235Q>EgnomAD
rs1349895448236R>CTOPMed
gnomAD
rs1349895448236R>GTOPMed
gnomAD
COSV51921608
rs1258439560
236R>H
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
TOPMed
dbSNP
gnomAD
rs1258439560236R>LTOPMed
gnomAD
rs748719351237M>VExAC
TOPMed
gnomAD
rs1335808336238L>PgnomAD
rs2038069171239V>ATOPMed
rs2038069251239V>LTOPMed
gnomAD
rs2038069251239V>MTOPMed
gnomAD
rs2038068971240Q>REnsembl
rs1308746346241R>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
dbSNP
gnomAD
rs1412533092241R>HTOPMed
gnomAD
rs1355284089242K>NgnomAD
rs76955156243D>E1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs779952471244E>*ExAC
gnomAD
COSV51922629
rs779952471
244E>K
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
dbSNP
gnomAD
COSV99315814
rs1383383176
246L>F
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
dbSNP
gnomAD
rs369160515247Q>*
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
ESP
ExAC
dbSNP
gnomAD
rs1007403856247Q>HEnsembl
rs1348637316248Q>RTOPMed
COSV51923716
rs746062824
250R>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
TOPMed
dbSNP
gnomAD
rs781032837250R>HExAC
TOPMed
gnomAD
rs781032837250R>LExAC
TOPMed
gnomAD
CA351522
COSV51920574
RCV000207121
rs869025244
rs869025244,COSV51920574
252R>C
Breast ductal adenocarcinoma (ClinVar)
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
Variant of uncertain significance (Ensembl, ClinVar, NCI-TCGA)ClinGen
NCI-TCGA Cosmic
ClinVar
TOPMed
dbSNP
gnomAD
rs763349779252R>HExAC
TOPMed
gnomAD
rs1308611658254L>SgnomAD
rs775682761255N>YExAC
gnomAD
rs1567502820256K>REnsembl
rs141822024257S>TESP
ExAC
TOPMed
rs371195118258S>CESP
TOPMed
gnomAD
rs371195118258S>FESP
TOPMed
gnomAD
rs771076863261D>EExAC
TOPMed
gnomAD
rs371217450262A>E1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs371217450262A>V1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs777406344263A>TExAC
gnomAD
rs1228811447264S>LgnomAD
rs1804880266S>RgnomAD
rs2038055127268L>PTOPMed
rs754545318269P>HExAC
TOPMed
gnomAD
rs754545318269P>RExAC
TOPMed
gnomAD
rs766159022270S>LExAC
TOPMed
gnomAD
rs1408414612271E>GTOPMed
gnomAD
rs760199296272G>CVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
rs138682084273A>VESP
ExAC
TOPMed
gnomAD
rs558619605274S>A1000Genomes
ExAC
TOPMed
gnomAD
rs558619605274S>P1000Genomes
ExAC
TOPMed
gnomAD
rs775848543275S>FExAC
TOPMed
gnomAD
rs1596889446276D>AEnsembl
COSV51919894
rs1253081413
rs1253081413,COSV51919894
278V>M
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
dbSNP
gnomAD
rs2038054219280L>PTOPMed
rs1223395210281R>CgnomAD
rs759617526281R>HExAC
gnomAD
COSV51921073
rs776654452
282R>*
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
TOPMed
dbSNP
gnomAD
rs200320761282R>QESP
ExAC
TOPMed
gnomAD
rs1342118061283R>MgnomAD
rs1278861908284M>ITOPMed
gnomAD
rs1234194548286A>TgnomAD
rs747167232286A>VExAC
TOPMed
gnomAD
COSV51923847
rs2038053688
287A>V
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
Ensembl
rs941073221288A>TTOPMed
rs1288021595289A>TTOPMed
rs771750137289A>VExAC
TOPMed
gnomAD
COSV51923585
rs754922563
291R>Q
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
TOPMed
dbSNP
gnomAD
rs145747194291R>WESP
ExAC
TOPMed
gnomAD
rs2038053117292R>TEnsembl
rs1487627493293L>VgnomAD
rs753418518294Q>RExAC
gnomAD
rs762776771295K>TExAC
gnomAD
COSV51923572
rs1232716103
296Q>*
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA Cosmic
TOPMed
dbSNP
gnomAD
rs750043281297Q>EExAC
gnomAD
rs764581795298T>PExAC
rs199784409299S>F1000Genomes
ExAC
TOPMed
gnomAD
VAR_035790
rs373191257
605D>V
a breast cancer sample; somatic mutation (UniProt)
Variant of uncertain significance (UniProt)UniProt
ESP
ExAC
TOPMed
dbSNP
gnomAD
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