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R4G4C9 · R4G4C9_RHOPR

Function

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Features

Showing features for active site, binding site.

144850100150200250300350400
Type
IDPosition(s)Description
Active site302Proton acceptor
Binding site345Fe cation (UniProtKB | ChEBI)
Binding site351Fe cation (UniProtKB | ChEBI)
Binding site360homogentisate (UniProtKB | ChEBI)
Binding site381Fe cation (UniProtKB | ChEBI)
Binding site381homogentisate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhomogentisate 1,2-dioxygenase activity
Molecular Functionmetal ion binding
Biological ProcessL-phenylalanine catabolic process
Biological Processtyrosine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homogentisate 1,2-dioxygenase
  • EC number
  • Alternative names
    • Homogentisate oxygenase
    • Homogentisic acid oxidase
    • Homogentisicase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Heteroptera > Panheteroptera > Cimicomorpha > Reduviidae > Triatominae > Rhodnius

Accessions

  • Primary accession
    R4G4C9

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-289Homogentisate 1,2-dioxygenase N-terminal
Domain290-441Homogentisate 1,2-dioxygenase C-terminal

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    448
  • Mass (Da)
    51,104
  • Last updated
    2013-06-26 v1
  • MD5 Checksum
    BEAE77B00F9AAC43FB1C799D9B074572
MAEVNFKYLTGFGNEFASEDPRCPNALPKGQNNPQKCPYGLYAEQLSGTAFTAPREFNKRSWLYRIRPSVLHDPYQKNELGYSPLNWEQKQREKLKELEEDCPNPNQMRWKPFPLPPNSRRIDWQEGLFPVAQAGDTASRNGLAVHIYLCNADMDKTALFNSDGDFLIVPQQGALKIKTEFGRMRVEPTEICVIQQGMRFSVSVEGPSRGYVLEIYGGHFQLPQLGPIGANGLANPRDFETPVAWFEDNNEEYIIKNKYQNTWWQVKQDHSPFDVVAWHGNYAPFKYDLKKFMTVNSVAYDHCDPSIFTVLTCPSNKPGTAIADFVIFPPRWSVAEHTFRPPYYHRNCMSEFMGLINGTYEAKEDGFAPGGGSLHSIMTPHGPDTDCFESASNAELKPMRLGDNALAFMFESSLGLKTTKWVNNYLDLNYHKCWEGLKKQFSQIKINV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACPB03017824
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KX572143
EMBL· GenBank· DDBJ
ANZ03347.1
EMBL· GenBank· DDBJ
mRNA
GAHY01001475
EMBL· GenBank· DDBJ
JAA76035.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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