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R4FP64 · R4FP64_RHOPR

Function

function

Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site157-166FAD (UniProtKB | ChEBI)
Binding site166substrate
Binding site190-192FAD (UniProtKB | ChEBI)
Binding site269substrate
Active site278Proton acceptor
Binding site304FAD (UniProtKB | ChEBI)
Binding site315FAD (UniProtKB | ChEBI)
Binding site372-376FAD (UniProtKB | ChEBI)
Binding site399-400substrate
Binding site401-403FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Function3-methylbutanoyl-CoA dehydrogenase activity
Molecular Functionflavin adenine dinucleotide binding
Biological ProcessL-leucine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isovaleryl-CoA dehydrogenase, mitochondrial
  • EC number
  • Alternative names
    • Butyryl-CoA dehydrogenase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Heteroptera > Panheteroptera > Cimicomorpha > Reduviidae > Triatominae > Rhodnius

Accessions

  • Primary accession
    R4FP64

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-152Acyl-CoA dehydrogenase/oxidase N-terminal
Domain156-253Acyl-CoA oxidase/dehydrogenase middle
Domain265-413Acyl-CoA dehydrogenase/oxidase C-terminal

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    46,346
  • Last updated
    2013-06-26 v1
  • MD5 Checksum
    05BE13857CDC07F19E2C4AF9A8DC75E4
MLGLFQFRLLKKCLNLQKVSSLCMSQYLPINDLLYGLTSEQQQLRDSVFNYTQKELAPKAEEIDKTDNFKEMREFWKGLGNLGALGITVEVEYGGTGGTYLDHVIIMEEISRASAAVGLSYGAHSNLCVNQIRLNGNEEQKMKYLPKLCSGEHIGALAMSEAEAGSNVVAMKIKAEKDGNHYILNGTKFWITNGPESDVLVVYAKTDSKAAKEHRGITAFIVEKNTPGFKVAQKLNKLGMRGSGTGELVFEDCRVPEENVLGALNKGIYVLYSGLNLERVVLSGGPLGIMQSCCDTAFEYVHNRQQFKQPIGTFQLMQGKIADMYTMLSSSRSYVYAVARACDNGNYDKKDCVGALFYSSASAVTVASEAIQCLGGNGYINDYPTGRYLRDAKLYEIGAGTQEIRKLVIGRELNSMYLQK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GAHY01001039
EMBL· GenBank· DDBJ
JAA76471.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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