R1F1Z6 · R1F1Z6_EMIHU

Function

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.

Features

Showing features for binding site, active site, site.

115152004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site1161Mg2+ 1 (UniProtKB | ChEBI)
Binding site1194Mg2+ 1 (UniProtKB | ChEBI)
Active site1291
Active site1335Proton donor/acceptor
Binding site1335Mg2+ 1 (UniProtKB | ChEBI)
Binding site1337Mg2+ 1 (UniProtKB | ChEBI)
Site1337Transition state stabilizer
Site1463Important for catalytic activity
Binding site1496Mg2+ 1 (UniProtKB | ChEBI)
Active site1497Proton acceptor
Binding site1497Mg2+ 1 (UniProtKB | ChEBI)
Site1497Interaction with DNA substrate

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    BRCT domain-containing protein

Gene names

    • ORF names
      EMIHUDRAFT_462994

Organism names

Accessions

  • Primary accession
    R1F1Z6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_501459259918-1515BRCT domain-containing protein

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region795-820Disordered
Region881-902Disordered
Domain1004-1083BRCT
Region1102-1147Disordered

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,515
  • Mass (Da)
    158,982
  • Last updated
    2013-06-26 v1
  • Checksum
    2D78FF0A303E59E9
MLVRLLPLVWWFGAASALHLAALHRRVAVGADSSLQLKVVYDADRLSPLPCVLFFSGADCSHESYMWLAERLARAGCAVALSSCVVPFGPKTCLLSTPFDLGALGSLEAYKRGPSRAGIAAILDELRALAAASDGPLAGRLDLGRLAVGGHSSGGRTALDLASFDEPFGVAAVFSYGASLVNSGMGAFAERGSVLPCDAARPPPLLLLGGSEDGVSAGLSESGDATETLRRTMAEGVAPGSGRAELCILRGANHMAFCEPVDPTCSAVDSDRPLGADGAAVRSALGALIVDFLGAAGVAGSRLAPEERTAALAPPLIFAADAVRVPEDARCVGAEVAAAGAATAAQPAGQAAAAAADEVAWEALRGGLRGSLDGFASPAVEWGVRYANEAAESGGGGGGAASGSAGAKSVGVNLWLTSRLPVPHMTLYVGVRAGRATLMADHLPRFDLGERPEHVAAFYGGEQASRWSAAQRVKGLTPFRSSDPSVRALQGPNALALHGAAADPHAVSALVAELDRHAGAWLGWVRTTPLLDDGAEAEAVTVHRDLGSFMAAKPGLEVLGDAGKPEVLVRAHAFAEPDWRSFDRPLANTPEGVYTYVHELAAAAGTESGPLAGPTICLKLKRREAVAAALGGTALDDLAAREGDAPDLEAARRVNQLACGWQPPPSLCAARSTGEPLRLELTGDRELLDAPDGPLGNKGGLYIESRVRVAPAEGNPSVLRVTSPTITTPLVGVPEQFRAGHYMKASVAAAAAKAKWVFKQEDKVVKRSGGESEYGEVIGDAQLLKEAADAEANELEAAADAAETAAGPRTPPGTPPPAAPPTRKYGCALCGSKLHNLTTTKKDERTVTCPYHNDFKAVIGKKDEVKYVKLNPKERMAKRAEEAAKKEEEAAKEEEEEEEGGPTMVLLEGTAVQLHGLVTRPEHNGRRGEVAGYDSSAGRYIVAVCGGLGPPTKLKLRRENLILPAASEPRAPTSLPAHLAKRPRCSAHAPSEAAPAAAPLAPVSKAAIFSGVRVLLAVRLPDKLRELQEGVVRRGGGDVVSDVREATHLALEPDRRPSELACLAALPQAEWPRLVTKEWVGQCSKVLSADGTRRDVLLKHRHPLDHRMASPADSPARTPPPPAGTATPPRDGGAAAGAAGPSEPVEAVPATADPRCIVAWNCCGLEKRLQSQRDSSALGDFLATRRPDLLFLSEVKMARERGDVSHCPKEEGDRRRILRAESTCLAGYECTFALGLKRAAGSAVLWRDGSAPRRLWRYLPDDLDAPPSDACDEDGRVLLTEWPSLLLLHTYSPNVGQTPESYRRRTNWDARVAEWAEHAASWASARGLAVVYMGDLNCAPQHEDVTWCRCNPKNRRGCACPLDACAQGSGATAGWMLAQHPSATDDGGFTGQNGVSPNERRGFAELLRRGGLVDAFRHHHPAPAGCPPPDPFADDTFSYRGWPGNDERDPAFAKYYRRGMRIDHALVSAALLPRVVACNILGAGESCAGAGFMGSDHAPIVLCLARGTSPRAADN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB864838
EMBL· GenBank· DDBJ
EOD29236.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp