R1F1Z6 · R1F1Z6_EMIHU
- ProteinBRCT domain-containing protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1515 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 1161 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 1194 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 1291 | |||||
Sequence: Y | ||||||
Active site | 1335 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 1335 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1337 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Site | 1337 | Transition state stabilizer | ||||
Sequence: N | ||||||
Site | 1463 | Important for catalytic activity | ||||
Sequence: D | ||||||
Binding site | 1496 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 1497 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 1497 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 1497 | Interaction with DNA substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoric diester hydrolase activity | |
Biological Process | base-excision repair |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameBRCT domain-containing protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Haptista > Haptophyta > Prymnesiophyceae > Isochrysidales > Noelaerhabdaceae > Emiliania
Accessions
- Primary accessionR1F1Z6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MLVRLLPLVWWFGAASA | ||||||
Chain | PRO_5014592599 | 18-1515 | BRCT domain-containing protein | |||
Sequence: LHLAALHRRVAVGADSSLQLKVVYDADRLSPLPCVLFFSGADCSHESYMWLAERLARAGCAVALSSCVVPFGPKTCLLSTPFDLGALGSLEAYKRGPSRAGIAAILDELRALAAASDGPLAGRLDLGRLAVGGHSSGGRTALDLASFDEPFGVAAVFSYGASLVNSGMGAFAERGSVLPCDAARPPPLLLLGGSEDGVSAGLSESGDATETLRRTMAEGVAPGSGRAELCILRGANHMAFCEPVDPTCSAVDSDRPLGADGAAVRSALGALIVDFLGAAGVAGSRLAPEERTAALAPPLIFAADAVRVPEDARCVGAEVAAAGAATAAQPAGQAAAAAADEVAWEALRGGLRGSLDGFASPAVEWGVRYANEAAESGGGGGGAASGSAGAKSVGVNLWLTSRLPVPHMTLYVGVRAGRATLMADHLPRFDLGERPEHVAAFYGGEQASRWSAAQRVKGLTPFRSSDPSVRALQGPNALALHGAAADPHAVSALVAELDRHAGAWLGWVRTTPLLDDGAEAEAVTVHRDLGSFMAAKPGLEVLGDAGKPEVLVRAHAFAEPDWRSFDRPLANTPEGVYTYVHELAAAAGTESGPLAGPTICLKLKRREAVAAALGGTALDDLAAREGDAPDLEAARRVNQLACGWQPPPSLCAARSTGEPLRLELTGDRELLDAPDGPLGNKGGLYIESRVRVAPAEGNPSVLRVTSPTITTPLVGVPEQFRAGHYMKASVAAAAAKAKWVFKQEDKVVKRSGGESEYGEVIGDAQLLKEAADAEANELEAAADAAETAAGPRTPPGTPPPAAPPTRKYGCALCGSKLHNLTTTKKDERTVTCPYHNDFKAVIGKKDEVKYVKLNPKERMAKRAEEAAKKEEEAAKEEEEEEEGGPTMVLLEGTAVQLHGLVTRPEHNGRRGEVAGYDSSAGRYIVAVCGGLGPPTKLKLRRENLILPAASEPRAPTSLPAHLAKRPRCSAHAPSEAAPAAAPLAPVSKAAIFSGVRVLLAVRLPDKLRELQEGVVRRGGGDVVSDVREATHLALEPDRRPSELACLAALPQAEWPRLVTKEWVGQCSKVLSADGTRRDVLLKHRHPLDHRMASPADSPARTPPPPAGTATPPRDGGAAAGAAGPSEPVEAVPATADPRCIVAWNCCGLEKRLQSQRDSSALGDFLATRRPDLLFLSEVKMARERGDVSHCPKEEGDRRRILRAESTCLAGYECTFALGLKRAAGSAVLWRDGSAPRRLWRYLPDDLDAPPSDACDEDGRVLLTEWPSLLLLHTYSPNVGQTPESYRRRTNWDARVAEWAEHAASWASARGLAVVYMGDLNCAPQHEDVTWCRCNPKNRRGCACPLDACAQGSGATAGWMLAQHPSATDDGGFTGQNGVSPNERRGFAELLRRGGLVDAFRHHHPAPAGCPPPDPFADDTFSYRGWPGNDERDPAFAKYYRRGMRIDHALVSAALLPRVVACNILGAGESCAGAGFMGSDHAPIVLCLARGTSPRAADN |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 795-820 | Disordered | ||||
Sequence: LEAAADAAETAAGPRTPPGTPPPAAP | ||||||
Region | 881-902 | Disordered | ||||
Sequence: EEAAKKEEEAAKEEEEEEEGGP | ||||||
Domain | 1004-1083 | BRCT | ||||
Sequence: SKAAIFSGVRVLLAVRLPDKLRELQEGVVRRGGGDVVSDVREATHLALEPDRRPSELACLAALPQAEWPRLVTKEWVGQC | ||||||
Region | 1102-1147 | Disordered | ||||
Sequence: HPLDHRMASPADSPARTPPPPAGTATPPRDGGAAAGAAGPSEPVEA |
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,515
- Mass (Da)158,982
- Last updated2013-06-26 v1
- Checksum2D78FF0A303E59E9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KB864838 EMBL· GenBank· DDBJ | EOD29236.1 EMBL· GenBank· DDBJ | Genomic DNA |