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R0CXX4 · R0CXX4_CAUVI

  • Protein
    Arginine biosynthesis bifunctional protein ArgJ
  • Gene
    argJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site201Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site202Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site238substrate
Binding site264substrate
Site274-275Cleavage; by autolysis
Active site275Nucleophile
Binding site275substrate
Binding site362substrate
Binding site485substrate
Binding site490substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      OR37_03016

Organism names

  • Taxonomic identifier
  • Strain
    • OR37
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Caulobacterales > Caulobacteraceae > Caulobacter

Accessions

  • Primary accession
    R0CXX4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50235675251-274Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023567524275-490Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-24Disordered
Region53-76Disordered

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    490
  • Mass (Da)
    51,141
  • Last updated
    2013-06-26 v1
  • MD5 Checksum
    12DCE51A9ABF025F7C081A942B941D7E
MTKTPKASGKTPAEKAPETAHNPVAAAGAALERALVDPLASALKRAGLRRAQKSAGEDVSIATPATPAAKPAATGAGKPGLAISPLAVPFPIIPPIAGVEIATGRAGFYKHEREDLLLMRFAEGTSAAGVFTRHGVGSAPVDWCKRQLAATGGADVRALVVNAGCANSFTGRPGADAVRRVATAVGKRLDCRQRDVMMASTGVIGVILDDSKITARLPEVESRLKADAWAEAGRAIMTTDTFPKGAYATAMIDGVEVKIAGICKGSGMIAPDMATMLAFVATDAAIAPAALQTLVSLYTRTTFNCVTVDGDRSTNDTLLLFATGQSGAPKIHRAGDKRLADFREKLEGVLLDLALQLVRDGEGATKFVKITVNGAESPASARKIARTIAESPLVKTAFAGEDANWGRIVMAVGRADEPVAREKINVRFGDLYAARDGLISAEYDEAKMSAYVKNAEFEVSVDVGVGKGSATVWTCDLTKQYVAINGDYRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
APMP01000021
EMBL· GenBank· DDBJ
ENZ81155.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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