Q9ZUL5 · CHR19_ARATH

Function

function

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity).
Probable chromatin remodeling factor. Probable helicase-like transcription factor involved in transcriptional gene silencing. Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin (PubMed:25420628).

Miscellaneous

Induction by the mutagens rose Bengal (RB) and methyl methane sulfonate (MMS) is enhanced in progeny of Chernobyl plants exposed to ionizing radiation thus leading to a higher resistance to DNA damages.

Features

Showing features for binding site.

1763100200300400500600700
TypeIDPosition(s)Description
Binding site239-246ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionATP-dependent chromatin remodeler activity
Molecular FunctionDNA binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity
Biological Processcellular response to UV-C
Biological ProcessDNA damage response
Biological ProcessDNA repair
Biological Processregulatory ncRNA-mediated gene silencing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein CHROMATIN REMODELING 19
  • EC number
  • Short names
    AtCHR19
  • Alternative names
    • AtRAD54-like protein

Gene names

    • Name
      ETL1
    • Synonyms
      CHR19
    • ORF names
      F5O4.14
    • Ordered locus names
      At2g02090

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9ZUL5

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004308561-763Protein CHROMATIN REMODELING 19

Proteomic databases

PTM databases

Expression

Induction

By UV-C illumination (PubMed:15053760).
Accumulates in response to the mutagens rose Bengal (RB) and methyl methane sulfonate (MMS) (PubMed:15133154).

Gene expression databases

Interaction

Subunit

Interacts with SUVR2 and itself.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, motif, coiled coil.

Type
IDPosition(s)Description
Region1-43Disordered
Region114-149Disordered
Compositional bias116-131Acidic residues
Domain226-404Helicase ATP-binding
Motif353-356DEAH box
Coiled coil462-482
Motif520-527Nuclear localization signal
Domain592-742Helicase C-terminal

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    763
  • Mass (Da)
    86,277
  • Last updated
    1999-05-01 v1
  • MD5 Checksum
    281F4D194EF6381750308BBE4D801154
MKRDFDEISEEEWSQHSFNASRVLKRPRTPKKTRAATNPTPSIESFAFRRPSTAMTIESNSSDGDCVEIEDLGDSDSDVKIVNGEDLLLEDEEEVEETKVVMRAARVGRRFVIEDEEASDDDDDEAESSASEDEFGGGGGGSGGRRGEDEDVVGKALQKCAKISADLRKELYGTSSGVTDRYSEVETSTVRIVTQNDIDDACKAEDSDFQPILKPYQLVGVNFLLLLYKKGIEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVLQYHGAARAAYSRELNSLSKAGKPPPFNVLLVCYSLFERHSEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLMSVARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRRLKSDVMQQLVPKIQRVEYVLMERKQEDAYKEAIEEYRAASQARLVKLSSKSLNSLAKALPKRQISNYFTQFRKIANHPLLIRRIYSDEDVIRIARKLHPIGAFGFECSLDRVIEEVKGFNDFRIHQLLFQYGVNDTKGTLSDKHVMLSAKCRTLAELLPSMKKSGHRVLIFSQWTSMLDILEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKSIFACLLSTRAGGQGLNLTGADTVIIHDMDFNPQIDRQAEDRCHRIGQTKPVTIFRLVTKSTVDENIYEIAKRKLVLDAAVLESGVHVDDNGDTPEKTMGEILASLLMG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias116-131Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC005936
EMBL· GenBank· DDBJ
AAC97224.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC05545.1
EMBL· GenBank· DDBJ
Genomic DNA
AY059857
EMBL· GenBank· DDBJ
AAL24339.1
EMBL· GenBank· DDBJ
mRNA
BT002576
EMBL· GenBank· DDBJ
AAO00936.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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