Q9ZSD4 · SY121_ARATH

Function

function

Vesicle trafficking protein that functions in the secretory pathway (By similarity).
Together with SYP61, regulates the post-Golgi trafficking of the aquaporin PIP2-7 to the plasma membrane, thus modulating cell membrane water permeability (PubMed:25082856).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell plate
Cellular Componentcytosol
Cellular Componentplasma membrane
Cellular Componentplasmodesma
Cellular ComponentSNARE complex
Cellular Componenttrans-Golgi network
Molecular Functionprotein-membrane adaptor activity
Molecular FunctionSNAP receptor activity
Biological Processdefense response
Biological Processdefense response to fungus
Biological Processintracellular protein transport
Biological Processmaintenance of protein location in plasma membrane
Biological Processnegative regulation of defense response
Biological Processprotein localization to plasma membrane
Biological Processprotein targeting to membrane
Biological Processregulation of stomatal movement
Biological Processresponse to abscisic acid
Biological Processresponse to fungus
Biological Processsecretion by cell
Biological Processtranspiration
Biological Processvesicle-mediated transport

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Syntaxin-121
  • Short names
    AtSYP121
  • Alternative names
    • Protein SYNTAXIN OF PLANTS 121
    • Syntaxin-related protein At-Syr1

Gene names

    • Name
      SYP121
    • Synonyms
      SYR1
    • ORF names
      F26K24.11
    • Ordered locus names
      At3g11820

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9ZSD4
  • Secondary accessions
    • F4J7G9

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
; Single-pass type IV membrane protein
Golgi apparatus, trans-Golgi network membrane
; Single-pass type IV membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-285Cytoplasmic
Transmembrane286-306Helical; Anchor for type IV membrane protein
Topological domain307-346Vesicular

Keywords

Phenotypes & Variants

Disruption phenotype

Abnormal PIP proteins (e.g. PIP1-4, PIP2-1 and PIP2-7) trafficking and subcellular localization leading to a reduced levels at the plasma membrane.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for modified residue, initiator methionine, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
Initiator methionine1In isoform Q9ZSD4-2; Removed
ChainPRO_00002102461-346Syntaxin-121
Modified residue2In isoform Q9ZSD4-2; N-acetylalanine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at low levels in roots, stems, flowers and leaves.

Induction

Ninefold induction within 30-min exposure to abscisic acid and after 48 hours drought stress.

Gene expression databases

Interaction

Subunit

Part of the t-SNARE complex (PubMed:11718726, PubMed:21826108).
Binds to SNAP33 (PubMed:11718726).
Colocalizes with SYP61 and PIP2-7 in trafficking vesicles and at the plasma membrane (PubMed:25082856).
Interacts with SYP61 and PIP2-7 (PubMed:25082856).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9ZSD4SNAP33 Q9S7P94EBI-4476863, EBI-603017

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, coiled coil, domain.

TypeIDPosition(s)Description
Region1-41Disordered
Coiled coil41-76
Domain214-276t-SNARE coiled-coil homology
Region314-346Disordered

Sequence similarities

Belongs to the syntaxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative initiation.

Q9ZSD4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    346
  • Mass (Da)
    37,957
  • Last updated
    1999-05-01 v1
  • Checksum
    8A6E2390761A8446
MNDLFSSSFSRFRSGEPSPRRDVAGGGDGVQMANPAGSTGGVNLDKFFEDVESVKEELKELDRLNETLSSCHEQSKTLHNAKAVKDLRSKMDGDVGVALKKAKMIKVKLEALDRANAANRSLPGCGPGSSSDRTRTSVLNGLRKKLMDSMDSFNRLRELISSEYRETVQRRYFTVTGENPDERTLDRLISTGESERFLQKAIQEQGRGRVLDTINEIQERHDAVKDIEKNLRELHQVFLDMAVLVEHQGAQLDDIESHVGRASSFIRGGTDQLQTARVYQKNTRKWTCIAIIILIIIITVVVLAVLKPWNNSSGGGGGGGGGGTTGGSQPNSGTPPNPPQARRLLR

Q9ZSD4-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0579471-31in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF112864
EMBL· GenBank· DDBJ
AAD11809.1
EMBL· GenBank· DDBJ
mRNA
AC016795
EMBL· GenBank· DDBJ
AAF23198.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE75102.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE75103.1
EMBL· GenBank· DDBJ
Genomic DNA
AY093151
EMBL· GenBank· DDBJ
AAM13150.1
EMBL· GenBank· DDBJ
mRNA
BT003393
EMBL· GenBank· DDBJ
AAO30056.1
EMBL· GenBank· DDBJ
mRNA
AY087842
EMBL· GenBank· DDBJ
AAM65395.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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