Q9ZSD4 · SY121_ARATH
- ProteinSyntaxin-121
- GeneSYP121
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids346 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Vesicle trafficking protein that functions in the secretory pathway (By similarity).
Together with SYP61, regulates the post-Golgi trafficking of the aquaporin PIP2-7 to the plasma membrane, thus modulating cell membrane water permeability (PubMed:25082856).
Together with SYP61, regulates the post-Golgi trafficking of the aquaporin PIP2-7 to the plasma membrane, thus modulating cell membrane water permeability (PubMed:25082856).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell plate | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Cellular Component | plasmodesma | |
Cellular Component | SNARE complex | |
Cellular Component | trans-Golgi network | |
Molecular Function | protein-membrane adaptor activity | |
Molecular Function | SNAP receptor activity | |
Biological Process | defense response | |
Biological Process | defense response to fungus | |
Biological Process | intracellular protein transport | |
Biological Process | maintenance of protein location in plasma membrane | |
Biological Process | negative regulation of defense response | |
Biological Process | protein localization to plasma membrane | |
Biological Process | protein targeting to membrane | |
Biological Process | regulation of stomatal movement | |
Biological Process | response to abscisic acid | |
Biological Process | response to fungus | |
Biological Process | secretion by cell | |
Biological Process | transpiration | |
Biological Process | vesicle-mediated transport |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSyntaxin-121
- Short namesAtSYP121
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9ZSD4
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type IV membrane protein
Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-285 | Cytoplasmic | ||||
Sequence: MNDLFSSSFSRFRSGEPSPRRDVAGGGDGVQMANPAGSTGGVNLDKFFEDVESVKEELKELDRLNETLSSCHEQSKTLHNAKAVKDLRSKMDGDVGVALKKAKMIKVKLEALDRANAANRSLPGCGPGSSSDRTRTSVLNGLRKKLMDSMDSFNRLRELISSEYRETVQRRYFTVTGENPDERTLDRLISTGESERFLQKAIQEQGRGRVLDTINEIQERHDAVKDIEKNLRELHQVFLDMAVLVEHQGAQLDDIESHVGRASSFIRGGTDQLQTARVYQKNTRK | ||||||
Transmembrane | 286-306 | Helical; Anchor for type IV membrane protein | ||||
Sequence: WTCIAIIILIIIITVVVLAVL | ||||||
Topological domain | 307-346 | Vesicular | ||||
Sequence: KPWNNSSGGGGGGGGGGTTGGSQPNSGTPPNPPQARRLLR |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Abnormal PIP proteins (e.g. PIP1-4, PIP2-1 and PIP2-7) trafficking and subcellular localization leading to a reduced levels at the plasma membrane.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for modified residue, initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Initiator methionine | 1 | In isoform Q9ZSD4-2; Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000210246 | 1-346 | Syntaxin-121 | |||
Sequence: MNDLFSSSFSRFRSGEPSPRRDVAGGGDGVQMANPAGSTGGVNLDKFFEDVESVKEELKELDRLNETLSSCHEQSKTLHNAKAVKDLRSKMDGDVGVALKKAKMIKVKLEALDRANAANRSLPGCGPGSSSDRTRTSVLNGLRKKLMDSMDSFNRLRELISSEYRETVQRRYFTVTGENPDERTLDRLISTGESERFLQKAIQEQGRGRVLDTINEIQERHDAVKDIEKNLRELHQVFLDMAVLVEHQGAQLDDIESHVGRASSFIRGGTDQLQTARVYQKNTRKWTCIAIIILIIIITVVVLAVLKPWNNSSGGGGGGGGGGTTGGSQPNSGTPPNPPQARRLLR | ||||||
Modified residue | 2 | In isoform Q9ZSD4-2; N-acetylalanine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed at low levels in roots, stems, flowers and leaves.
Induction
Ninefold induction within 30-min exposure to abscisic acid and after 48 hours drought stress.
Gene expression databases
Interaction
Subunit
Part of the t-SNARE complex (PubMed:11718726, PubMed:21826108).
Binds to SNAP33 (PubMed:11718726).
Colocalizes with SYP61 and PIP2-7 in trafficking vesicles and at the plasma membrane (PubMed:25082856).
Interacts with SYP61 and PIP2-7 (PubMed:25082856).
Binds to SNAP33 (PubMed:11718726).
Colocalizes with SYP61 and PIP2-7 in trafficking vesicles and at the plasma membrane (PubMed:25082856).
Interacts with SYP61 and PIP2-7 (PubMed:25082856).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9ZSD4 | SNAP33 Q9S7P9 | 4 | EBI-4476863, EBI-603017 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-41 | Disordered | ||||
Sequence: MNDLFSSSFSRFRSGEPSPRRDVAGGGDGVQMANPAGSTGG | ||||||
Coiled coil | 41-76 | |||||
Sequence: GVNLDKFFEDVESVKEELKELDRLNETLSSCHEQSK | ||||||
Domain | 214-276 | t-SNARE coiled-coil homology | ||||
Sequence: INEIQERHDAVKDIEKNLRELHQVFLDMAVLVEHQGAQLDDIESHVGRASSFIRGGTDQLQTA | ||||||
Region | 314-346 | Disordered | ||||
Sequence: GGGGGGGGGGTTGGSQPNSGTPPNPPQARRLLR |
Sequence similarities
Belongs to the syntaxin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative initiation.
Q9ZSD4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length346
- Mass (Da)37,957
- Last updated1999-05-01 v1
- Checksum8A6E2390761A8446
Q9ZSD4-2
- Name2
- Differences from canonical
- 1-31: Missing
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_057947 | 1-31 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF112864 EMBL· GenBank· DDBJ | AAD11809.1 EMBL· GenBank· DDBJ | mRNA | ||
AC016795 EMBL· GenBank· DDBJ | AAF23198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE75102.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE75103.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY093151 EMBL· GenBank· DDBJ | AAM13150.1 EMBL· GenBank· DDBJ | mRNA | ||
BT003393 EMBL· GenBank· DDBJ | AAO30056.1 EMBL· GenBank· DDBJ | mRNA | ||
AY087842 EMBL· GenBank· DDBJ | AAM65395.1 EMBL· GenBank· DDBJ | mRNA |