Q9ZS91 · MSRB5_ARATH
- ProteinPeptide methionine sulfoxide reductase B5
- GeneMSRB5
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids139 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. MSRB family specifically reduces the MetSO R-enantiomer (By similarity).
Catalytic activity
- L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol
RHEA-COMP:12313 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = RHEA-COMP:12314 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 51 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 54 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 97 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 100 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 122 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | metal ion binding | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Biological Process | protein repair | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide methionine sulfoxide reductase B5
- EC number
- Short namesAtMSRB5
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9ZS91
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylalanine | |||
Chain | PRO_0000395523 | 2-139 | Peptide methionine sulfoxide reductase B5 | ||
Disulfide bond | 69↔122 | Redox-active | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 12-133 | MsrB | |||
Sequence similarities
Belongs to the MsrB Met sulfoxide reductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
Q9ZS91-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length139
- Mass (Da)15,251
- Last updated1999-05-01 v1
- Checksum6133EB2603675AF6
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4JGY0 | F4JGY0_ARATH | MSRB5 | 129 |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF118223 EMBL· GenBank· DDBJ | AAD03444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161501 EMBL· GenBank· DDBJ | CAB80848.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE82429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY059946 EMBL· GenBank· DDBJ | AAL24428.1 EMBL· GenBank· DDBJ | mRNA | ||
AY081609 EMBL· GenBank· DDBJ | AAM10171.1 EMBL· GenBank· DDBJ | mRNA | ||
AY088697 EMBL· GenBank· DDBJ | AAM67017.1 EMBL· GenBank· DDBJ | mRNA |