When frataxin is combined with AtNFS1 and AtISD11 the ferrochelatse activity is increased. These results suggest that frataxin could be the iron donor in the final step of heme synthesis in plant mitochondria and constitutes an important advance in the elucidation of the mechanisms of heme synthesis in plants.
Frataxin deficiency alters the normal functioning of chloroplasts by affecting the levels of Fe chlorophyll and the photosynthetic electron transport chain in this organelle.
AtFH apart from its role in protecting bioavailable iron within mitochondria and the biogenesis of Fe-S groups also plays a role in the biosynthesis of heme groups in plants.
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