Q9ZKR8 · QUED_HELPJ

Function

function

Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13Zn2+ (UniProtKB | ChEBI)
Active site23Proton acceptor
Binding site28Zn2+ (UniProtKB | ChEBI)
Binding site30Zn2+ (UniProtKB | ChEBI)
Active site68Charge relay system
Active site136Charge relay system

GO annotations

AspectTerm
Molecular Function6-carboxy-5,6,7,8-tetrahydropterin synthase activity
Molecular Functionmetal ion binding
Biological Processqueuosine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-carboxy-5,6,7,8-tetrahydropterin synthase
  • EC number
  • Short names
    CPH4 synthase
  • Alternative names
    • Queuosine biosynthesis protein QueD

Gene names

    • Name
      queD
    • Ordered locus names
      jhp_0867

Organism names

Accessions

  • Primary accession
    Q9ZKR8

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000579271-2006-carboxy-5,6,7,8-tetrahydropterin synthase

Structure

Family & Domains

Sequence similarities

Belongs to the PTPS family. QueD subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    23,630
  • Last updated
    1999-05-01 v1
  • Checksum
    21CD23D840BBCF2A
MVIRRLYKFCASHVVRNCSSLKCAQNIHGHNYEVEVFIETNRLDNANMALDFGLMQQEMQTFIDSFDHAHHFWDKESPEFQRFIENHCVRYVKCSFNLSAESYALMFLYYLTKILQKSVFSNNEGELKVSSVRVHETKNGYAESFLKDLENPHFKSLVHDHCVSFSQGIQSLWHDKDFFHKIISDEKQCFFHAKPLHQIP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE001439
EMBL· GenBank· DDBJ
AAD06439.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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