Q9ZKR8 · QUED_HELPJ
- Protein6-carboxy-5,6,7,8-tetrahydropterin synthase
- GenequeD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids200 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
Miscellaneous
The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).
Catalytic activity
- 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H+ + triphosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 13 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 23 | Proton acceptor | ||||
Sequence: C | ||||||
Binding site | 28 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 30 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 68 | Charge relay system | ||||
Sequence: H | ||||||
Active site | 136 | Charge relay system | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 6-carboxy-5,6,7,8-tetrahydropterin synthase activity | |
Molecular Function | metal ion binding | |
Biological Process | queuosine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-carboxy-5,6,7,8-tetrahydropterin synthase
- EC number
- Short namesCPH4 synthase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionQ9ZKR8
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000057927 | 1-200 | 6-carboxy-5,6,7,8-tetrahydropterin synthase | |||
Sequence: MVIRRLYKFCASHVVRNCSSLKCAQNIHGHNYEVEVFIETNRLDNANMALDFGLMQQEMQTFIDSFDHAHHFWDKESPEFQRFIENHCVRYVKCSFNLSAESYALMFLYYLTKILQKSVFSNNEGELKVSSVRVHETKNGYAESFLKDLENPHFKSLVHDHCVSFSQGIQSLWHDKDFFHKIISDEKQCFFHAKPLHQIP |
Structure
Family & Domains
Sequence similarities
Belongs to the PTPS family. QueD subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length200
- Mass (Da)23,630
- Last updated1999-05-01 v1
- Checksum21CD23D840BBCF2A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE001439 EMBL· GenBank· DDBJ | AAD06439.1 EMBL· GenBank· DDBJ | Genomic DNA |