Q9ZJN9 · UNG_HELPJ

Function

function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

Catalytic activity

  • Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
    EC:3.2.2.27 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

123320406080100120140160180200220
TypeIDPosition(s)Description
Active site70Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionuracil DNA N-glycosylase activity
Biological Processbase-excision repair, AP site formation via deaminated base removal

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil-DNA glycosylase
  • EC number
  • Short names
    UDG

Gene names

    • Name
      ung
    • Ordered locus names
      jhp_1266

Organism names

Accessions

  • Primary accession
    Q9ZJN9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001761031-233Uracil-DNA glycosylase

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    233
  • Mass (Da)
    26,331
  • Last updated
    1999-05-01 v1
  • Checksum
    8639FF2A62968CC3
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFCAFNLTPPYAVKIILLGQDPYHSTYLENEQELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVPVPCCGDLSAWAKRGMLLLNAILSVEKNQAASHKYIGWEAFSDQILIRLFETTTPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSVQKAYREVYRKDFDFSL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE001439
EMBL· GenBank· DDBJ
AAD06857.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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