Q9ZH99 · IDH_COXBU
- ProteinIsocitrate dehydrogenase [NADP]
- Geneicd
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids427 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate and carbon dioxide with the concomitant reduction of NADP+.
Catalytic activity
- D-threo-isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 Mg2+ or Mn2+ ion per subunit.
pH Dependence
Optimum pH is 6.5-7.7.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 114 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 123 | D-threo-isocitrate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 125 | D-threo-isocitrate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 129 | D-threo-isocitrate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 139 | D-threo-isocitrate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 163 | D-threo-isocitrate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Site | 170 | Critical for catalysis | ||||
Sequence: Y | ||||||
Site | 240 | Critical for catalysis | ||||
Sequence: K | ||||||
Binding site | 317 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 349-355 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: HGTAPKY | ||||||
Binding site | 362 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 401 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 405 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | isocitrate dehydrogenase (NADP+) activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | NAD binding | |
Biological Process | glyoxylate cycle | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIsocitrate dehydrogenase [NADP]
- EC number
- Short namesIDH
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Coxiellaceae > Coxiella
Accessions
- Primary accessionQ9ZH99
- Secondary accessions
Proteomes
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 20 | in strain: GQ212, KoQ229, SQ217 | ||||
Sequence: Q → E | ||||||
Natural variant | 32 | in strain: TK-1 | ||||
Sequence: E → V | ||||||
Natural variant | 33 | in strain: GQ212 | ||||
Sequence: V → A | ||||||
Natural variant | 52 | in strain: GQ212, KoQ229, MAN, ME, Priscilla, SQ217 | ||||
Sequence: A → T | ||||||
Natural variant | 63 | in strain: ME | ||||
Sequence: V → A | ||||||
Natural variant | 87 | in strain: SQ217 | ||||
Sequence: V → A | ||||||
Natural variant | 100 | in strain: California 76 VR 614 | ||||
Sequence: E → G | ||||||
Natural variant | 104 | in strain: 605 | ||||
Sequence: E → G | ||||||
Natural variant | 183 | in strain: Priscilla | ||||
Sequence: V → M | ||||||
Natural variant | 271 | in strain: Bangui VR 730 | ||||
Sequence: G → R | ||||||
Natural variant | 306 | in strain: Bangui VR 730 | ||||
Sequence: Y → C | ||||||
Natural variant | 379 | in strain: El Tayeb RSA 342 | ||||
Sequence: W → R | ||||||
Natural variant | 415 | in strain: GQ212, KoQ229, SQ217 | ||||
Sequence: T → A | ||||||
Natural variant | 419 | in strain: GQ212, KoQ229, SQ217 | ||||
Sequence: G → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 14 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000323713 | 1-427 | Isocitrate dehydrogenase [NADP] | |||
Sequence: MTELTGVSIVTYQHIKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL |
Expression
Developmental stage
Detected in both the small cell variant (SCV) and in the large cell variant (LCV) stage (at protein level). LCVs are more metabolically active than SCVs.
Interaction
Structure
Sequence
- Sequence statusComplete
- Length427
- Mass (Da)46,636
- Last updated1999-05-01 v1
- ChecksumE23462962C26C138
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF069035 EMBL· GenBank· DDBJ | AAC68600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146284 EMBL· GenBank· DDBJ | AAF16725.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146285 EMBL· GenBank· DDBJ | AAF16726.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146286 EMBL· GenBank· DDBJ | AAF16727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146287 EMBL· GenBank· DDBJ | AAF16728.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146288 EMBL· GenBank· DDBJ | AAF16729.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146289 EMBL· GenBank· DDBJ | AAF16730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146290 EMBL· GenBank· DDBJ | AAF16731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146291 EMBL· GenBank· DDBJ | AAF16732.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146292 EMBL· GenBank· DDBJ | AAF16733.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146293 EMBL· GenBank· DDBJ | AAF16734.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146294 EMBL· GenBank· DDBJ | AAF16735.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146295 EMBL· GenBank· DDBJ | AAF16736.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146296 EMBL· GenBank· DDBJ | AAF16737.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146297 EMBL· GenBank· DDBJ | AAF16738.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146298 EMBL· GenBank· DDBJ | AAF16739.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146299 EMBL· GenBank· DDBJ | AAF16740.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146300 EMBL· GenBank· DDBJ | AAF16741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF146301 EMBL· GenBank· DDBJ | AAF16742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE016828 EMBL· GenBank· DDBJ | AAO90709.2 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |