Q9ZER9 · TRPE_BUCPS

Function

function

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Activity regulation

Feedback inhibited by tryptophan.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site40L-tryptophan (UniProtKB | ChEBI)
Binding site291-293L-tryptophan (UniProtKB | ChEBI)
Binding site328-329chorismate (UniProtKB | ChEBI)
Binding site361Mg2+ (UniProtKB | ChEBI)
Binding site449chorismate (UniProtKB | ChEBI)
Binding site469chorismate (UniProtKB | ChEBI)
Binding site483-485chorismate (UniProtKB | ChEBI)
Binding site485chorismate (UniProtKB | ChEBI)
Binding site498Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionanthranilate synthase activity
Molecular Functionmetal ion binding
Biological Processtryptophan biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anthranilate synthase component 1
  • EC number
  • Short names
    AS; ASI

Gene names

    • Name
      trpE

Encoded on

  • Plasmid pBPs2

Organism names

Accessions

  • Primary accession
    Q9ZER9

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001540841-520Anthranilate synthase component 1

Interaction

Subunit

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    520
  • Mass (Da)
    59,502
  • Last updated
    1999-05-01 v1
  • Checksum
    8637ABA7947D6135
MKNRRYEVEILQIEGIYQSDPTTIFNQLCNKKKCTLLLESAEIDKKHALESMIIIDSALRISSLDNIVTIEALTENGKSLLFKLDLLLPLTVKNVLFENSRRLIFPFINHEIDEDKKLRSVSIFDTFRLLIKTMKIPKNLTKSMFFGGLFSYDLVNNFEKLPILNRNQKCPDLCFYLAETLLILDHKKKNCIIQSSLFNRKSSEKNRLKKNLQEIKTKLTQNVPKIEHRKIDQISLKCNLTDKEYIKIIKKMKQSIKKGDIFQVVPSRKFYLPCISSLSAYQRLKQSNPSPYMFFMQDSDFTLFGASPESSLKYDSKSKKIEIYPIAGTRPRGKTENGLIDLDLDSKIELEMRMNEKELSEHLMLVDLARNDLARICEPGSRYVASLTKVDRYSCVMHLVSKIVGRLKSNLDIFHAYCACMNMGTLTGAPKIKAMELISKFEKERRGSYGGSIGYFTESNNFDTCIIIRSAYVENNLATVQAGAGIVLDSVPQEEANESRNKAQAVIQAIIYAHSSREVV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ012334
EMBL· GenBank· DDBJ
CAA09996.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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