Q9ZCE9 · PBPA_RICPR

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site87Proton donor; for transglycosylase activity
Active site457Acyl-ester intermediate; for transpeptidase activity

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1A
  • Short names
    PBP-1a; PBP1a

Including 2 domains:

  • Recommended name
    Penicillin-insensitive transglycosylase
  • EC number
  • Alternative names
    • Peptidoglycan TGase
  • Recommended name
    Penicillin-sensitive transpeptidase
  • EC number
  • Alternative names
    • DD-transpeptidase

Gene names

    • Name
      mrcA
    • Synonyms
      ponA
    • Ordered locus names
      RP807

Organism names

Accessions

  • Primary accession
    Q9ZCE9

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-6Cytoplasmic
Transmembrane7-27Helical; Signal-anchor for type II membrane protein
Topological domain28-787Periplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000831741-787Penicillin-binding protein 1A

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region49-220Transglycosylase
Region398-711Transpeptidase

Sequence similarities

In the N-terminal section; belongs to the glycosyltransferase 51 family.
In the C-terminal section; belongs to the transpeptidase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    787
  • Mass (Da)
    88,694
  • Last updated
    1999-05-01 v1
  • Checksum
    E9BF4429D17A32D0
MYKSLFLCLKIFAVLILIGCSVTAYIIYHYSHDLPDYSQLARYYPPSVTRIYSRDGKLIEEYAFERRVFVPINNVPSSLIESFIAAEDKNFYTHPGIDLLGIVRAAFLNISNYLHNRRMEGASTITQQVVKNFLLTNEVSLERKIKEVIISYMISRIFTKHQILELYLNQTFFGRGAYGVAAAAQNYFNKSVEELTIAESAFIAALPKAPSELNPDKNYSRVKARRDYVIERMFEDGYITRDTMKEAIGSPIVLRKRAKEETVTADYYAEQVREEVIRMLNSKEEFYRGGLTIITSLDAKMQQLAENSLRKGLREFDRKSGFRKPIANIPLDNWQEELKKLPTPSSLLEYKLAVVLDVSDNHAKIGLIDGSKAKIPIVEMQWARSNLKSVKTLLKKGDVIVVEPIKDCYALRQIPEVNGAIMVMNPHTGQVLASVGGYDFSTSKFDRVTQALRQPGSLSKTFVYLAALENGVKPNQIFNDGPIEIIQGPGMPSWCPKNYEGQFLGDMTMRTGFEKSRNLITVRVATAVGLTKIVDIIKRFGINNEPKKVYSMVLGSIETTLSRITNAYAIIANGGKKVEPHFVELIQDRNGKIIYRRDNRECFSCNIADSDLDTAILEIPKEDIYRVTDEASNYQITSFLTGAIDSGTGYAARKLGKIIAGKTGTSNDSKDTWFIGFTPKIVVGSYVGYDTPKELGKKATGSNVVLPIFIDFMNHAYKDEPSLPFKVPDSIKLIAVDRITGKMIPNGTVIEAFKVNNIQMLENDYMIDNHDIFDYVPGMLDQSQEIY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ235273
EMBL· GenBank· DDBJ
CAA15233.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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