Q9ZC94 · HOLC_RICPR
- ProteinProbable DNA polymerase III subunit chi
- Geneholc
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids165 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | DNA-directed DNA polymerase activity | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable DNA polymerase III subunit chi
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Rickettsiaceae > Rickettsieae > Rickettsia > typhus group
Accessions
- Primary accessionQ9ZC94
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000101428 | 1-165 | Probable DNA polymerase III subunit chi | |||
Sequence: MKFLIEDNIKFMQQFSIYHTSNELFLKAILRLIEKCYYSNFKSVILTTDVHQQEMLNKNLWTYSRKQFIPHGSKFDPQPAKQPIYITDELQNPNNASVLVIISPTDIAKILQVKEYIKVFKRIIIITDLLENLKELIIKINKFTGQENKIDCFTQNPIGTWNKIA |
Interaction
Subunit
DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex. Interacts directly with the psi subunit (holD). The only subunit of the DNA polymerase III holoenzyme known to interact with single-stranded DNA binding protein (SSB) (By similarity).
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length165
- Mass (Da)19,411
- Last updated1999-05-01 v1
- Checksum305290A3A14024C4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ235273 EMBL· GenBank· DDBJ | CAA15296.1 EMBL· GenBank· DDBJ | Genomic DNA |