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Q9ZAB8 · NPD_AGGAC

Function

function

NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site10-29NAD+ (UniProtKB | ChEBI)
Binding site54substrate
Binding site57substrate
Binding site87-90NAD+ (UniProtKB | ChEBI)
Active site105Proton acceptor
Binding site170-172NAD+ (UniProtKB | ChEBI)
Binding site197-199NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functionprotein-malonyllysine demalonylase activity
Molecular Functionprotein-succinyllysine desuccinylase activity
Molecular Functiontransferase activity
Biological Processprotein deacetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB

Organism names

Accessions

  • Primary accession
    Q9ZAB8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001102851-208NAD-dependent protein deacylase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-208Deacetylase sirtuin-type

Domain

2 residues (Tyr-54 and Arg-57) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.

Sequence similarities

Belongs to the sirtuin family. Class III subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    22,861
  • Last updated
    1999-05-01 v1
  • MD5 Checksum
    3FA0583681583DD5E1C9149229E2F7F5
MKPICVVLSGAGISAESGIPTYRAEDGLWAGHKIEDVCTPEALQRNRKQVLAFYNERRRNCAEAKPNAAHKVLVELERSYNVQIITQNVEDLHERAGSTNVLHLHGELTKARSSFDPDYIVPCMGDQSVNDKDPNGHPMRPHIVFFGESVPVLEPAIDLVSQADIVLVIGTSLQVYPANGLVNEAPKNAQIYLIDPNPNTGFNPVTGW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF006830
EMBL· GenBank· DDBJ
AAC70895.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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