Q9Z5X5 · NIFS_FRASE

Function

function

Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Features

Showing features for binding site, active site.

141950100150200250300350400
TypeIDPosition(s)Description
Binding site69-70pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site157pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site185pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site205-207pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site245pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Active site333Cysteine persulfide intermediate
Binding site333[2Fe-2S] cluster (UniProtKB | ChEBI); via persulfide group

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functioncysteine desulfurase activity
Molecular Functioniron-sulfur cluster binding
Molecular Functionmetal ion binding
Biological Processiron-sulfur cluster assembly
Biological Processnitrogen fixation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cysteine desulfurase
  • EC number
  • Alternative names
    • Nitrogenase metalloclusters biosynthesis protein NifS

Gene names

    • Name
      nifS

Organism names

Accessions

  • Primary accession
    Q9Z5X5

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001502551-419Cysteine desulfurase
Modified residue208N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region392-419Disordered
Compositional bias405-419Polar residues

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    419
  • Mass (Da)
    43,333
  • Last updated
    1999-05-01 v1
  • Checksum
    E112EB80EE6D0D2E
MIYLDHNATTPVDPRVVEVMLPLFTERFANPASKHAPGQEATRIVERARREVASLAGARPREIVFTSGATEAANLAIGGVLATAEPGRRRILVGATEHPAVLGAADAAVSAGSAVSADGTTAAERIAVHPDGTVDVDDLRRRLGPDVALVAVMAANNETGAVNDPRPLVEAARSAGRCCCADVTQALGRVPVEFERTGVDLAVSSAHKLYGPKGVGALIASKDAWSRLAPRVHGGGQERGLRAGTLNTAGIAGFGAAARIAAESMADDGTRQRALVALLTELLVKRLGPGAVELNGPVRARLPNTVNLRFVGAGADEVQACAPRVAISAGSACSGGGDEPSHVLRAMGRTATEARESLRFSLGRATTTEEIRTAADLVARAVLRVRSLSQSTPIQDEVRDDNRASSNSLNRGSAASKES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias405-419Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF119361
EMBL· GenBank· DDBJ
AAD17272.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp