Q9Z2Q6 · SEPT5_MOUSE
- ProteinSeptin-5
- GeneSeptin5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids369 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Filament-forming cytoskeletal GTPase (By similarity).
Involved in cytokinesis (Potential). May play a role in platelet secretion
Involved in cytokinesis (Potential). May play a role in platelet secretion
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 51-58 | GTP (UniProtKB | ChEBI) | ||||
Sequence: GESGLGKS | ||||||
Binding site | 85 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 111 | GTP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 190-198 | GTP (UniProtKB | ChEBI) | ||||
Sequence: KADCLVPSE | ||||||
Binding site | 248 | GTP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 263 | GTP (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon terminus | |
Cellular Component | calyx of Held | |
Cellular Component | cell cortex | |
Cellular Component | cell division site | |
Cellular Component | cleavage furrow | |
Cellular Component | microtubule cytoskeleton | |
Cellular Component | plasma membrane | |
Cellular Component | presynapse | |
Cellular Component | septin complex | |
Cellular Component | septin ring | |
Cellular Component | stress fiber | |
Cellular Component | synapse | |
Cellular Component | synaptic vesicle | |
Cellular Component | terminal bouton | |
Molecular Function | GDP binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | molecular adaptor activity | |
Molecular Function | phosphatidylinositol binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | syntaxin binding | |
Biological Process | adult behavior | |
Biological Process | cytoskeleton-dependent cytokinesis | |
Biological Process | positive regulation of exocytosis | |
Biological Process | protein localization | |
Biological Process | regulation of exocytosis | |
Biological Process | regulation of synaptic vesicle docking | |
Biological Process | social behavior |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSeptin-5
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9Z2Q6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Mice have a normal life-span and show no apparent abnormalities, including synaptic properties and hippocampal neuron growth. In platelets, hyperresponsive degranulation phenotype.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000173523 | 1-369 | Septin-5 | |||
Sequence: MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERINQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNSECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKDRIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQKMKQQMQDQ | ||||||
Modified residue | 13 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 168 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 225 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 327 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 336 | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Phosphorylated by DYRK1A.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Detected at 17 dpc in the brain. Expression increases during postnatal life and reaches a plateau at approximately P10 (at protein level).
Gene expression databases
Interaction
Subunit
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
Interacts with SEPTIN2 and SEPTIN5. Interaction with SEPTIN4 not detected. In platelets, associated with a complex containing STX4 (By similarity).
Interacts with PRKN; this interaction leads to SEPTIN5 ubiquitination and degradation (PubMed:11078524).
Interacts with DYRK1A (PubMed:18938227).
Interacts with STX1A; in the cerebellar cortex (PubMed:17296554).
Interacts with SEPTIN2 and SEPTIN5. Interaction with SEPTIN4 not detected. In platelets, associated with a complex containing STX4 (By similarity).
Interacts with PRKN; this interaction leads to SEPTIN5 ubiquitination and degradation (PubMed:11078524).
Interacts with DYRK1A (PubMed:18938227).
Interacts with STX1A; in the cerebellar cortex (PubMed:17296554).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | Q9Z2Q6 | PRKN O60260 | 2 | EBI-772125, EBI-716346 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 41-314 | Septin-type G | ||||
Sequence: KGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERINQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNSECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKDRIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQ | ||||||
Region | 51-58 | G1 motif | ||||
Sequence: GESGLGKS | ||||||
Region | 108-111 | G3 motif | ||||
Sequence: DTPG | ||||||
Region | 189-192 | G4 motif | ||||
Sequence: AKAD | ||||||
Coiled coil | 338-369 | |||||
Sequence: DAETEKLIRMKDEELRRMQEMLQKMKQQMQDQ |
Sequence similarities
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length369
- Mass (Da)42,748
- Last updated2005-12-06 v2
- ChecksumD58468DBA9ADE626
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A338P755 | A0A338P755_MOUSE | Septin5 | 126 | ||
A0A338P769 | A0A338P769_MOUSE | Septin5 | 378 | ||
A0A338P729 | A0A338P729_MOUSE | Septin5 | 248 | ||
B7ZNM7 | B7ZNM7_MOUSE | Septin5 | 381 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK134700 EMBL· GenBank· DDBJ | BAE22248.1 EMBL· GenBank· DDBJ | mRNA | ||
BC059848 EMBL· GenBank· DDBJ | AAH59848.1 EMBL· GenBank· DDBJ | mRNA | ||
BC141073 EMBL· GenBank· DDBJ | AAI41074.1 EMBL· GenBank· DDBJ | mRNA | ||
BC145331 EMBL· GenBank· DDBJ | AAI45332.1 EMBL· GenBank· DDBJ | mRNA | ||
AF033350 EMBL· GenBank· DDBJ | AAC83974.1 EMBL· GenBank· DDBJ | mRNA |