Q9Z2J0 · S23A1_MOUSE

  • Protein
    Solute carrier family 23 member 1
  • Gene
    Slc23a1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sodium:L-ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each L-ascorbate (PubMed:36749388).
Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (By similarity) (PubMed:36749388).

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
646 μMurate
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
430.1 pmol/min/mgtoward urate

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasal plasma membrane
Cellular Componentcytoplasm
Cellular Componentintracellular organelle
Cellular Componentplasma membrane
Molecular Functiondehydroascorbic acid transmembrane transporter activity
Molecular FunctionL-ascorbate:sodium symporter activity
Molecular FunctionL-ascorbic acid transmembrane transporter activity
Molecular Functionsodium ion transmembrane transporter activity
Molecular Functionurate transmembrane transporter activity
Biological Processbrain development
Biological Processdehydroascorbic acid transport
Biological ProcessL-ascorbic acid transmembrane transport
Biological Processlung development
Biological Processresponse to toxic substance
Biological Processsodium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier family 23 member 1
  • Alternative names
    • Na(+)/L-ascorbic acid transporter 1
    • Sodium-dependent vitamin C transporter 1
    • Yolk sac permease-like molecule 3

Gene names

    • Name
      Slc23a1
    • Synonyms
      Svct1, Yspl3

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9Z2J0
  • Secondary accessions
    • Q3TNA2
    • Q8C3M2
    • Q91WR7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-59Cytoplasmic
Transmembrane60-80Helical
Topological domain81-88Extracellular
Transmembrane89-109Helical
Topological domain110Cytoplasmic
Transmembrane111-131Helical
Topological domain132-166Extracellular
Transmembrane167-187Helical
Topological domain188-214Cytoplasmic
Transmembrane215-232Helical
Topological domain233-236Extracellular
Intramembrane237-250Helical
Topological domain251-257Extracellular
Transmembrane258-278Helical
Topological domain279-319Cytoplasmic
Transmembrane320-340Helical
Topological domain341-365Extracellular
Transmembrane366-386Helical
Topological domain387-409Cytoplasmic
Transmembrane410-430Helical
Topological domain431-433Extracellular
Transmembrane434-454Helical
Topological domain455-464Cytoplasmic
Transmembrane465-485Helical
Topological domain486-497Extracellular
Transmembrane498-518Helical
Topological domain519-605Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001659761-605Solute carrier family 23 member 1
Glycosylation145N-linked (GlcNAc...) asparagine
Glycosylation151N-linked (GlcNAc...) asparagine
Modified residue598Phosphothreonine
Modified residue600Phosphoserine
Modified residue603Phosphothreonine

Post-translational modification

Phosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in kidney (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-30Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    605
  • Mass (Da)
    65,554
  • Last updated
    2002-10-19 v2
  • Checksum
    A3F64CB42DA1CFF5
MKTPEDPGSPKQHEVVDSAGTSTRDRQAPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKSILALERWKCPSEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSMVEVVIGLMGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRVQIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGIPEVDQILTVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSETSASLKSYDFPFGMGMVKRTTFFRYIPICPVFRGFSKKTQNQPPVLEDTPDNIETGSVCTKV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A494BAL1A0A494BAL1_MOUSESlc23a153

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict205in Ref. 1; AAC78805
Sequence conflict223in Ref. 2; BAC39457
Sequence conflict540-541in Ref. 2; BAC39457
Sequence conflict579in Ref. 2; BAC39457

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF058318
EMBL· GenBank· DDBJ
AAC78805.1
EMBL· GenBank· DDBJ
mRNA
AK085499
EMBL· GenBank· DDBJ
BAC39457.1
EMBL· GenBank· DDBJ
mRNA
AK143959
EMBL· GenBank· DDBJ
BAE25631.1
EMBL· GenBank· DDBJ
mRNA
AK165439
EMBL· GenBank· DDBJ
BAE38187.1
EMBL· GenBank· DDBJ
mRNA
BC013528
EMBL· GenBank· DDBJ
AAH13528.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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