Q9Z266 · SNAPN_MOUSE
- ProteinSNARE-associated protein Snapin
- GeneSnapin
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids136 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for Q9Z266
Biogenesis of lysosome-related organelles complex-1 (BORC) regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol- 3,5-bisphosphate.
- CategoriesFunction, Subcellular Location
- SourceMGI: 1333745
The sperm-associated antigen 6 interactome and its role in spermatogenesis.
- CategoriesInteraction, Subcellular Location
- SourceMGI: 1333745
Structural and Functional Characterization of the Interaction of Snapin with the Dopamine Transporter: Differential Modulation of Psychostimulant Actions.
- Annotationsnapin/DAT interaction represents a direct link between exocytotic and reuptake mechanisms.
- CategoriesFunction, Interaction, Subcellular Location
- SourceGeneRif: 20615
Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons.
- CategoriesFunction, Subcellular Location
- SourceMGI: 1333745
Physical and functional interaction of Snapin with Cav1.3 calcium channel impacts channel protein trafficking in atrial myocytes.
- AnnotationThese results provide the evidence of a direct regulatory role of Snapin on Cav1.3 channels in atrial myocytes.
- CategoriesInteraction
- SourceGeneRif: 20615
High-throughput discovery of novel developmental phenotypes.
- CategoriesSequences, Phenotypes & Variants
- SourceMGI: 1333745
Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.
- AnnotationSnapin-dysbindin interaction regulates synaptic vesicle positional priming through BLOC-1/AP-3-dependent sorting.
- CategoriesSubcellular Location
BORC, a multisubunit complex that regulates lysosome positioning.
- CategoriesFunction, Subcellular Location
- SourceMGI: 1333745
Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons.
- AnnotationSnapin reduces APP processing by enhancing BACE1 lysosomal degradation.
- CategoriesPhenotypes & Variants
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1333745
Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.
- AnnotationTransmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.
- CategoriesInteraction
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP- 25.
- CategoriesInteraction, PTM / Processing, Interaction
Snapin accelerates exocytosis at low intracellular calcium concentration in mouse chromaffin cells.
- AnnotationSnapin accelerates exocytosis at low intracellular calcium concentration in mouse chromaffin cells.
- CategoriesFunction
- SourceGeneRif: 20615
Snapin recruits dynein to BDNF-TrkB signaling endosomes for retrograde axonal transport and is essential for dendrite growth of cortical neurons.
- AnnotationSnapin-dynein coupling is one of the primary mechanisms driving BDNF-TrkB retrograde transport thus providing mechanistic insights into the regulation of neuronal growth and survival.
- CategoriesFunction, Phenotypes & Variants
Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking.
- CategoriesInteraction, Subcellular Location
- SourceMGI: 1333745
Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.
- AnnotationAC6-mediated inhibition of neurite outgrowth was reversed by the overexpression of Snap25 or a Snapin mutant that could not be phosphorylated.
- CategoriesFunction, Interaction, Interaction, Function, Interaction
A conditional knockout resource for the genome-wide study of mouse gene function.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1333745
Snapin mediates incretin action and augments glucose-dependent insulin secretion.
- AnnotationPKA-dependent phosphorylation of snapin increases interaction among insulin secretory vesicle-associated proteins thereby potentiating glucose-stimulated insulin secretion.
- CategoriesPTM / Processing
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
- CategoriesExpression
- SourceMGI: 1333745
Uncovering the role of Snapin in regulating autophagy-lysosomal function.
- AnnotationSnapin has a role in regulating autophagy-lysosomal function
- CategoriesSubcellular Location
- SourceGeneRif: 20615
Snapin deficiency is associated with developmental defects of the central nervous system.
- AnnotationSnapin deficiency leads to reduced cell density in cortical plates apoptotic death in the cortex & third ventricle enhanced membrane-bound LC3-II staining and accumulation of polyubiquitinated proteins in the cortex and hippocampus in knockout mice
- CategoriesPhenotypes & Variants
Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons.
- Annotationhighlights new mechanistic insights into how Snapin-intermediate chain coordinates retrograde transport and late endosomal-lysosomal trafficking critical for autophagy-lysosomal function and thus neuronal homeostasis.
- CategoriesSubcellular Location
Mapped toEHD1 is a synaptic protein that modulates exocytosis through binding to snapin.
- CategoriesInteraction
- SourceMGI: 1333745